Numerous drug treatments that have recently entered the clinic or clinical trials have their
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …

β-Cell replacement by in situ reprogramming of non-β-cells is a promising diabetes therapy.
Following the observation that near-total β-cell ablation in adult mice triggers the …

To form new blood vessels (angiogenesis), endothelial cells (ECs) must be activated and
acquire highly migratory and proliferative phenotypes. However, the molecular mechanisms …

Defective coronary network function and insufficient blood supply are both cause and
consequence of myocardial infarction. Efficient revascularization after infarction is essential …

In contrast to mice, zebrafish have an exceptional yet elusive ability to replenish lost β cells
in adulthood. Understanding this framework would provide mechanistic insights for β cell …

Diabetes mellitus (DM) is one of the principal manifestations of metabolic syndrome and its
prevalence with modern lifestyle is increasing incessantly. Chronic hyperglycemia can …

Diabetes can be caused by an insufficiency in β-cell mass. Here, we performed a genetic
screen in a zebrafish model of β-cell loss to identify pathways promoting β-cell regeneration …

Aims/hypothesis Recovering functional beta cell mass is a promising approach for future
diabetes therapies. The aim of the present study is to investigate the effects of adjudin, a …

Progression from the initial vascular response upon hyperglycemia to a proliferative stage
with neovacularizations is the hallmark of proliferative diabetic retinopathy. Here, we report …

Glucose homeostasis depends on regulated insulin secretion from pancreatic β cells, which
acquire their mature phenotype postnatally. The functional maturation of β cells is regulated …