Targeting RNA structures with small molecules
JL Childs-Disney, X Yang, QMR Gibaut… - Nature Reviews Drug …, 2022 - nature.com
RNA adopts 3D structures that confer varied functional roles in human biology and
dysfunction in disease. Approaches to therapeutically target RNA structures with small …
dysfunction in disease. Approaches to therapeutically target RNA structures with small …
RNA drugs and RNA targets for small molecules: principles, progress, and challenges
RNA-based therapies, including RNA molecules as drugs and RNA-targeted small
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …
[HTML][HTML] Principles for targeting RNA with drug-like small molecules
KD Warner, CE Hajdin, KM Weeks - Nature reviews Drug discovery, 2018 - nature.com
RNA molecules are essential for cellular information transfer and gene regulation, and
RNAs have been implicated in many human diseases. Messenger and non-coding RNAs …
RNAs have been implicated in many human diseases. Messenger and non-coding RNAs …
Targeting RNA with small molecules: from fundamental principles towards the clinic
Recent advances in our understanding of RNA biology have uncovered crucial roles for
RNA in multiple disease states, ranging from viral and bacterial infections to cancer and …
RNA in multiple disease states, ranging from viral and bacterial infections to cancer and …
DNA-encoded library screening to inform design of a ribonuclease targeting chimera (RiboTAC)
Ribonuclease targeting chimeras (RiboTACs) induce degradation of an RNA target by
facilitating an interaction between an RNA and a ribonuclease (RNase). We describe the …
facilitating an interaction between an RNA and a ribonuclease (RNase). We describe the …
The emerging role of RNA as a therapeutic target for small molecules
CM Connelly, MH Moon, JS Schneekloth - Cell chemical biology, 2016 - cell.com
Recent advances in understanding different RNAs and unique features of their biology have
revealed a wealth of information. However, approaches to identify small molecules that …
revealed a wealth of information. However, approaches to identify small molecules that …
Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALAT1
Metastasis-associated lung adenocarcinoma transcript 1 (Malat1/MALAT1, mouse/human),
a highly conserved long noncoding (lnc) RNA, has been linked with several physiological …
a highly conserved long noncoding (lnc) RNA, has been linked with several physiological …
Machine learning informs RNA‐binding chemical space
Small molecule targeting of RNA has emerged as a new frontier in medicinal chemistry, but
compared to the protein targeting literature our understanding of chemical matter that binds …
compared to the protein targeting literature our understanding of chemical matter that binds …
A specific domain within the 3′ untranslated region of Usutu virus confers resistance to the exonuclease ISG20
J Zoladek, P El Kazzi, V Caval, V Vivet-Boudou… - Nature …, 2024 - nature.com
Usutu virus (USUV) and West Nile virus (WNV) are two closely related emerging mosquito-
borne flaviviruses. Their natural hosts are wild birds, but they can also cause severe …
borne flaviviruses. Their natural hosts are wild birds, but they can also cause severe …
Small molecules targeting viral RNA
T Hermann - Wiley Interdisciplinary Reviews: RNA, 2016 - Wiley Online Library
Highly conserved noncoding RNA (ncRNA) elements in viral genomes and transcripts offer
new opportunities to expand the repertoire of drug targets for the development of …
new opportunities to expand the repertoire of drug targets for the development of …