There has long been a fascination in the DNA repair pathways of archaea, for two main
reasons. Firstly, many archaea inhabit extreme environments where the rate of physical …

The CRISPR system in bacteria and archaea provides adaptive immunity against mobile
genetic elements. Type III CRISPR systems detect viral RNA, resulting in the activation of …

The tree of life shows the relationship between all organisms based on their common
ancestry. Until 1977, it comprised two major branches: prokaryotes and eukaryotes. Work by …

Application of CRISPR-based technologies in non-model microorganisms is currently very
limited. Here, we reported efficient genome engineering of an important industrial …

Sulfolobus islandicus is a model microorganism in the TACK superphylum of the Archaea, a
key lineage in the evolutionary history of cells. Here we report a genome-wide identification …

The three-dimensional organization of chromosomes can have a profound impact on their
replication and expression. The chromosomes of higher eukaryotes possess discrete …

Chromosome conformation capture (3C) technologies have identified topologically
associating domains (TADs) and larger A/B compartments as two salient structural features …

Archaea often thrive in environmental extremes, enduring levels of heat, pressure, salinity,
pH, and radiation that prove intolerable to most life. Many environmental extremes raise the …

Highlights•Sulfolobus spp. are adapted to two extremes high temperature (80 C) and low pH
(pH 2–3), which is not found in any other platform organisms so far.•Sulfolobus spp. are easy …

Characterizing the molecular interactions of viruses in natural microbial populations offers
insights into virus–host dynamics in complex ecosystems. We identify the resistance of …