The essential elements of Alzheimer's disease
Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …
The neurobiology of zinc in health and disease
The use of zinc in medicinal skin cream was mentioned in Egyptian papyri from 2000 BC (for
example, the Smith Papyrus), and zinc has apparently been used fairly steadily throughout …
example, the Smith Papyrus), and zinc has apparently been used fairly steadily throughout …
Copper dyshomeostasis in neurodegenerative diseases—therapeutic implications
G Gromadzka, B Tarnacka, A Flaga… - International journal of …, 2020 - mdpi.com
Copper is one of the most abundant basic transition metals in the human body. It takes part
in oxygen metabolism, collagen synthesis, and skin pigmentation, maintaining the integrity …
in oxygen metabolism, collagen synthesis, and skin pigmentation, maintaining the integrity …
Oxidative stress and the pathogenesis of Alzheimer′ s disease
Y Zhao, B Zhao - Oxidative medicine and cellular longevity, 2013 - Wiley Online Library
Alzheimer′ s disease (AD) is the most common neurodegenerative disease that causes
dementia in the elderly. Patients with AD suffer a gradual deterioration of memory and other …
dementia in the elderly. Patients with AD suffer a gradual deterioration of memory and other …
Metabolism and functions of copper in brain
IF Scheiber, JFB Mercer, R Dringen - Progress in neurobiology, 2014 - Elsevier
Copper is an important trace element that is required for essential enzymes. However, due
to its redox activity, copper can also lead to the generation of toxic reactive oxygen species …
to its redox activity, copper can also lead to the generation of toxic reactive oxygen species …
Biological metals and metal-targeting compounds in major neurodegenerative diseases
Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …
Metals in Alzheimer's and Parkinson's diseases
There has been steadily growing interest in the participation of metal ions (especially, zinc,
copper, and iron) in neurobiological processes, such as the regulation of synaptic …
copper, and iron) in neurobiological processes, such as the regulation of synaptic …
Metal dyshomeostasis and oxidative stress in Alzheimer's disease
MA Greenough, J Camakaris, AI Bush - Neurochemistry international, 2013 - Elsevier
Alzheimer's disease is the leading cause of dementia in the elderly and is defined by two
pathological hallmarks; the accumulation of aggregated amyloid beta and excessively …
pathological hallmarks; the accumulation of aggregated amyloid beta and excessively …
Copper, zinc and iron in neurodegenerative diseases (Alzheimer's, Parkinson's and prion diseases)
The basic role of metal ions including copper, zinc and iron in neurological pathologies is
generally accepted. The relationship between the development of disease and particular …
generally accepted. The relationship between the development of disease and particular …
[HTML][HTML] Therapeutics for Alzheimer's disease based on the metal hypothesis
Alzheimer's disease is the most common form of dementia in the elderly, and it is
characterized by elevated brain iron levels and accumulation of copper and zinc in cerebral …
characterized by elevated brain iron levels and accumulation of copper and zinc in cerebral …