Voltage-gated calcium channels are the primary mediators of depolarization-induced
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …

▪ Abstract Voltage-gated Ca2+ channels mediate Ca2+ entry into cells in response to
membrane depolarization. Electrophysiological studies reveal different Ca2+ currents …

The neuronal-type (N-type) voltage-gated calcium (Cav) channels, which are designated
Cav2. 2, have an important role in the release of neurotransmitters,–. Ziconotide is a Cav2. 2 …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

Brain-derived neurotrophic factor (BDNF) plays a critical role in synaptic physiology, as well
as mechanisms underlying various neuropsychiatric diseases and their treatment. Despite …

Synapses are specialized intercellular junctions in which cell adhesion molecules connect
the presynaptic machinery for neurotransmitter release to the postsynaptic machinery for …

Synaptic vesicles store neurotransmitters that are released during calcium-regulated
exocytosis. The specificity of neurotransmitter release requires the localization of both …

The oceans are the source of a large group of structurally unique natural products that are
mainly accumulated in invertebrates such as sponges, tunicates, bryozoans, and molluscs …

Ziconotide (PRIALT®) is a neuroactive peptide in the final stages of clinical development as
a novel non-opioid treatment for severe chronic pain. It is the synthetic equivalent of ω …

Morphological, electrophysiological, and biochemical properties of H9c2 cells, a permanent
cell line derived from rat cardiac tissue, were studied. Although the lectin binding pattern …