Origin and evolution of spliceosomal introns
Evolution of exon-intron structure of eukaryotic genes has been a matter of long-standing,
intensive debate. The introns-early concept, later rebranded 'introns first'held that protein …
intensive debate. The introns-early concept, later rebranded 'introns first'held that protein …
Genomic views of distant-acting enhancers
In contrast to protein-coding sequences, the significance of variation in non-coding DNA in
human disease has been minimally explored. A great number of recent genome-wide …
human disease has been minimally explored. A great number of recent genome-wide …
Ultraconserved elements anchor thousands of genetic markers spanning multiple evolutionary timescales
Although massively parallel sequencing has facilitated large-scale DNA sequencing,
comparisons among distantly related species rely upon small portions of the genome that …
comparisons among distantly related species rely upon small portions of the genome that …
Deep conservation of the enhancer regulatory code in animals
INTRODUCTION In animals, gene regulatory networks specify cell identity in space and
time. Transcription of genes in these networks is modulated by a class of cis-regulatory …
time. Transcription of genes in these networks is modulated by a class of cis-regulatory …
De novo mutations in regulatory elements in neurodevelopmental disorders
We previously estimated that 42% of patients with severe developmental disorders carry
pathogenic de novo mutations in coding sequences. The role of de novo mutations in …
pathogenic de novo mutations in coding sequences. The role of de novo mutations in …
[HTML][HTML] Ultraconserved enhancers are required for normal development
Non-coding" ultraconserved" regions containing hundreds of consecutive bases of perfect
sequence conservation across mammalian genomes can function as distant-acting …
sequence conservation across mammalian genomes can function as distant-acting …
Target enrichment of ultraconserved elements from arthropods provides a genomic perspective on relationships among H ymenoptera
Gaining a genomic perspective on phylogeny requires the collection of data from many
putatively independent loci across the genome. Among insects, an increasingly common …
putatively independent loci across the genome. Among insects, an increasingly common …
The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator
J Feng, C Bi, BS Clark, R Mady, P Shah… - Genes & …, 2006 - genesdev.cshlp.org
The identification of ultraconserved noncoding sequences in vertebrates has been
associated with developmental regulators and DNA-binding proteins. One of the first of …
associated with developmental regulators and DNA-binding proteins. One of the first of …
Ultraconserved elements are novel phylogenomic markers that resolve placental mammal phylogeny when combined with species-tree analysis
Phylogenomics offers the potential to fully resolve the Tree of Life, but increasing genomic
coverage also reveals conflicting evolutionary histories among genes, demanding new …
coverage also reveals conflicting evolutionary histories among genes, demanding new …
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
We report a high-quality draft of the genome sequence of the grey, short-tailed opossum
(Monodelphis domestica). As the first metatherian ('marsupial') species to be sequenced, the …
(Monodelphis domestica). As the first metatherian ('marsupial') species to be sequenced, the …