Type VI secretion system effector proteins: effective weapons for bacterial competitiveness
The Type VI secretion system (T6SS) is a protein translocation nanomachine widespread
among Gram‐negative bacteria and used as a means to deliver effectors directly into target …
among Gram‐negative bacteria and used as a means to deliver effectors directly into target …
Killing in the name of: T6SS structure and effector diversity
The life of bacteria is challenging, to endure bacteria employ a range of mechanisms to
optimize their environment, including deploying the type VI secretion system (T6SS). Acting …
optimize their environment, including deploying the type VI secretion system (T6SS). Acting …
[HTML][HTML] Highly accurate protein structure prediction with AlphaFold
Proteins are essential to life, and understanding their structure can facilitate a mechanistic
understanding of their function. Through an enormous experimental effort 1, 2, 3, 4, the …
understanding of their function. Through an enormous experimental effort 1, 2, 3, 4, the …
Identification of type VI secretion system effector-immunity pairs using structural bioinformatics
AM Geller, M Shalom, D Zlotkin, N Blum… - Molecular Systems …, 2024 - embopress.org
The type VI secretion system (T6SS) is an important mediator of microbe–microbe and
microbe–host interactions. Gram-negative bacteria use the T6SS to inject T6SS effectors …
microbe–host interactions. Gram-negative bacteria use the T6SS to inject T6SS effectors …
Activity, delivery, and diversity of Type VI secretion effectors
D Jurėnas, L Journet - Molecular Microbiology, 2021 - Wiley Online Library
The bacterial type VI secretion system (T6SS) system is a contractile secretion apparatus
that delivers proteins to neighboring bacterial or eukaryotic cells. Antibacterial effectors are …
that delivers proteins to neighboring bacterial or eukaryotic cells. Antibacterial effectors are …
Bacterial type VI secretion system (T6SS): an evolved molecular weapon with diverse functionality
Bacterial secretion systems are nanomolecular complexes that release a diverse set of
virulence factors/or proteins into its surrounding or translocate to their target host cells …
virulence factors/or proteins into its surrounding or translocate to their target host cells …
Presence and absence of type VI secretion systems in bacteria
The type VI secretion system (T6SS) is a molecular puncturing device that enables Gram-
negative bacteria to kill competitors, manipulate host cells and take up nutrients. Who would …
negative bacteria to kill competitors, manipulate host cells and take up nutrients. Who would …
Structure of a Rhs effector clade domain provides mechanistic insights into type VI secretion system toxin delivery
The type VI secretion system (T6SS) is a molecular machine utilised by many Gram-negative
bacteria to deliver antibacterial toxins into adjacent cells. Here we present the structure of …
bacteria to deliver antibacterial toxins into adjacent cells. Here we present the structure of …
Substrate recruitment mechanism by gram-negative type III, IV, and VI bacterial injectisomes
Bacteria use a wide arsenal of macromolecular substrates (DNA and proteins) to interact
with or infect prokaryotic and eukaryotic cells. To do so, they utilize substrate-injecting …
with or infect prokaryotic and eukaryotic cells. To do so, they utilize substrate-injecting …
Combining high throughput and high quality for cryo-electron microscopy data collection
F Weis, WJH Hagen - Biological Crystallography, 2020 - journals.iucr.org
Cryo-electron microscopy (cryo-EM) can be used to elucidate the 3D structure of
macromolecular complexes. Driven by technological breakthroughs in electron-microscope …
macromolecular complexes. Driven by technological breakthroughs in electron-microscope …