Histone modifications are thought to regulate chromatin structure, transcription and other
nuclear processes. Histone methylation was originally believed to be an irreversible …

The discovery of an increasing number of histone demethylases has highlighted the
dynamic nature of the regulation of histone methylation, a key chromatin modification that is …

Because nucleosomes are widely replaced by protamine in mature human sperm, the
epigenetic contributions of sperm chromatin to embryo development have been considered …

RNA polymerase (Pol) III transcribes many noncoding RNAs (for example, transfer RNAs)
important for translational capacity and other functions. We localized Pol III, alternative TFIIIB …

Since the discovery of the first histone lysine demethylase in 2004, two protein families with
numerous members have been identified that demethylate various histone lysine residues …

Kdm1a is a histone demethylase linked to intellectual disability with essential roles during
gastrulation and the terminal differentiation of specialized cell types, including neurons, that …

Schizosaccharomyces pombe is an ascomycete fungus that divides by medial fission; it is
thus commonly referred to as fission yeast, as opposed to the distantly related budding yeast …

Biochemical analysis of molecular interactions in specific genomic regions requires their
isolation while retaining molecular interactions in vivo. Here, we report isolation of telomeres …

Heterochromatic gene silencing at the pericentromeric DNA repeats in fission yeast requires
the RNA interference (RNAi) machinery. The RNA-induced transcriptional silencing (RITS) …

All living organisms need to duplicate their genetic information while protecting it from
unwanted mutations, which can lead to genetic disorders and cancer development …