Transcription factor nuclear factor erythroid 2‐related factor 2 (Nrf2) is a major regulator of
antioxidant response element‐(ARE‐) driven cytoprotective protein expression. The …

Respiratory diseases are one of the most common pediatric diseases in clinical practice.
Their pathogenesis, diagnosis, and treatment are thus worthy of further investigation. The …

Work-related asthma is highly prevalent and represents a significant societal and financial
burden worldwide. This State of the Art series article explores the epidemiology, clinical …

Nrf2 is essential to antioxidant response element (ARE)-mediated host defense.
Sulforaphane (SFN) is a phytochemical antioxidant known to affect multiple cellular targets …

Oxidative stress induced by cigarette smoke and other environmental pollutants contributes
to refractory asthma. To better understand the role of smoking in asthma, we investigated the …

Non-communicable chronic diseases (NCDs) are most commonly characterized by age-
related loss of homeostasis and/or by cumulative exposures to environmental factors, which …

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates
the metabolism of xenobiotics. There is growing evidence that the AhR is implicated in …

Background and Purpose Cysteinyl leukotrienes (CysLTs) are pro‐inflammatory lipid
mediators that exacerbate disease state in several asthma phenotypes including asthma …

Oxidant stress modifies T lymphocyte activation and function. Previous work demonstrated
that murine T cell–specific kelch like-ECH-associated protein 1 (Keap1) deletion enhances …

Isothiocyanates (ITCs) belong to a group of natural products that possess a highly reactive
electrophilic− N= C= S functional group. They are stored in plants as precursor molecules …