“Sola dosis facit venenum.” These words of Paracelsus,“the dose makes the poison”, can
lead to a cavalier attitude concerning potential toxicities of the vast array of low abundance …

Abstract Sten Orrenius, MD, Ph. D., pioneered many areas of cellular and molecular
toxicology and made seminal contributions to our knowledge of oxidative stress and …

The exposome is the cumulative measure of environmental influences and associated
biological responses throughout the lifespan, including exposures from the environment …

Aging is by far the most prominent risk factor for Alzheimer's disease (AD), and both aging
and AD are associated with apparent metabolic alterations. As develo** effective …

Background Over the past 20 years, advances in genomic technology have enabled
unparalleled access to the information contained within the human genome. However, the …

Paraquat (PQ) is a non-selective herbicide and is exceedingly toxic to humans. The
mechanism of PQ toxicity is very complex and has not been clearly defined. There is no …

Background Parkinson's disease (PD) is the second most common neurodegenerative
disorder whose prevalence is rapidly increasing worldwide. The molecular mechanisms …

Occupational and environmental exposure to pesticides may induce harmful effects on
human health by promoting the development of a wide range of disorders. Some of the most …

Maneb is a typical dithiocarbamate fungicide that has been extensively used worldwide.
Epidemiological evidence shows that exposure to maneb is an environmental risk factor for …

Paraquat (PQ) is an herbicide toxin that induces injury in different organs. The anti‐
inflammatory and antioxidant effects of carvacrol were reported previously. The effects of …