Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination
Background The dietary consumption of cuprizone–a copper chelator–has long been known
to induce demyelination of specific brain structures and is widely used as model of multiple …
to induce demyelination of specific brain structures and is widely used as model of multiple …
CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities
Remyelination, the myelin regenerative response that follows demyelination, restores
saltatory conduction and function and sustains axon health. Its declining efficiency with …
saltatory conduction and function and sustains axon health. Its declining efficiency with …
SYK coordinates neuroprotective microglial responses in neurodegenerative disease
Recent studies have begun to reveal critical roles for the brain's professional phagocytes,
microglia, and their receptors in the control of neurotoxic amyloid beta (Aβ) and myelin …
microglia, and their receptors in the control of neurotoxic amyloid beta (Aβ) and myelin …
TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis
Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease
of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are …
of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are …
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis
The repair of inflamed, demyelinated lesions as in multiple sclerosis (MS) necessitates the
clearance of cholesterol-rich myelin debris by microglia/macrophages and the switch from a …
clearance of cholesterol-rich myelin debris by microglia/macrophages and the switch from a …
Transcriptional and epigenetic decoding of the microglial aging process
As important immune cells, microglia undergo a series of alterations during aging that
increase the susceptibility to brain dysfunctions. However, the longitudinal characteristics of …
increase the susceptibility to brain dysfunctions. However, the longitudinal characteristics of …
Microglia in central nervous system inflammation and multiple sclerosis pathology
Microglia are the resident macrophages of the central nervous system (CNS). They have
important physiological functions in maintaining tissue homeostasis but also contribute to …
important physiological functions in maintaining tissue homeostasis but also contribute to …
Microglia in multiple sclerosis: Protectors turn destroyers
VW Yong - Neuron, 2022 - cell.com
Microglia are implicated in all stages of multiple sclerosis (MS). Microglia alterations are
detected by positron emission tomography in people living with MS prior to the formation of …
detected by positron emission tomography in people living with MS prior to the formation of …
Regenerating CNS myelin—from mechanisms to experimental medicines
Although the core concept of remyelination—based on the activation, migration, proliferation
and differentiation of CNS progenitors—has not changed over the past 20 years, our …
and differentiation of CNS progenitors—has not changed over the past 20 years, our …
The pro-remyelination properties of microglia in the central nervous system
Microglia are resident macrophages of the CNS that are involved in its development,
homeostasis and response to infection and damage. Microglial activation is a common …
homeostasis and response to infection and damage. Microglial activation is a common …