Efficient drug delivery systems (DDSs) play a pivotal role in ensuring pharmaceuticals'
targeted and effective administration. However, the intricate interplay between drug …

Poorly water-soluble drugs are frequently encountered and present a most challengeable
difficulty in pharmaceutical development. Poor solubility of drugs can lead to suboptimal …

The processes used by academic and industrial scientists to discover new drugs have
recently experienced a true renaissance, with many new and exciting techniques being …

Camptothecin (CPT) is a potent anti-cancer agent targeting topoisomerase I (TOP1).
However, CPT has poor pharmacokinetic properties, causes toxicities, and leads to drug …

CYP17A1 is an enzyme that plays a major role in steroidogenesis and is critically involved in
the biosynthesis of steroid hormones. Therefore, it remains an attractive target in several …

Deep eutectic solvents (DESs) are commonly used in pharmaceutical applications as
excellent solubilizers of active substances. This study investigated the tuning of ibuprofen …

Accurately predicting molecular properties is a challenging but essential task in drug
discovery. Recently, many mono-modal deep learning methods have been successfully …

This review provides a comprehensive overview of recent advancements in the design and
synthesis of biologically active quaternary ammonium compounds (QACs). The covered …

Vector-borne diseases, constituting over 17% of infectious diseases, are caused by
parasites, viruses, and bacteria, and their prevalence is shaped by environmental and social …

The field of drug discovery is continually advancing with the emergence of new technologies
and scientific developments. Moreover, there is a recent growing interest in exploiting …