Abnormal energy metabolism, as one of the important hallmarks of cancer, was induced by
multiple carcinogenic factors and tumor-specific microenvironments. It comprises aerobic …

Colorectal cancer (CRC) represents a significant global health burden, with high incidence
and mortality rates worldwide. Recent progress in research highlights the distinct clinical …

Purpose: Mutations of the isocitrate dehydrogenase (IDH) gene are common genetic
mutations in human malignancies. Increasing evidence indicates that IDH mutations play …

Abstract p62 is an important multifunctional adaptor protein participating in autophagy and
many other activities. Many studies have revealed that p62 is highly expressed in multiple …

Glycolytic metabolism generates energy and intermediates for biomass production. Tumor-
associated glycolysis is upregulated compared to normal tissues in response to tumor cell …

Glucose metabolism is essential for the activation, differentiation and function of T cells and
proper glucose metabolism is required to maintain effective T cell immunity. Dysregulation of …

Energy metabolic reprogramming is frequently observed during tumor progression as tumor
cells necessitate adequate energy production for rapid proliferation. Although current …

Increasing evidence indicates that 2-hydroxyglutarate (2HG) is an oncometabolite that
drives tumour formation and progression. Due to mutations in isocitrate dehydrogenase …

Abstract Background Abnormal activation of Wnt/β‐catenin signaling is associated with
various aspects of cancer development. This study explored the roles of novel target genes …

Objective. To study the expression and correlation of insulin receptor (INSR), insulin
receptor substrate‐1 (IRS‐1), and programmed cell death ligand‐1 (PD‐L1) in nonsmall cell …