Bone remodeling is essential for adult bone homeostasis. It comprises two phases: bone
formation and resorption. The balance between the two phases is crucial for sustaining bone …

Growth hormone (GH) and its mediator, the insulin-like growth factor-1 (IGF-1) regulate
somatic growth, metabolism and many aspects of aging. As such, actions of GH/IGF have …

Puberty is a defining phase of human development where growth ends and the ability to
reproduce begins. An understanding of the events leading up to puberty highlights the fact …

Background. Growth hormone (GH) and insulin‐like growth factor (IGF‐1) are fundamental
in skeletal growth during puberty and bone health throughout life. GH increases tissue …

Endochondral ossification is the process by which the embryonic cartilaginous model of
most bones contributes to longitudinal growth and is gradually replaced by bone. During …

Aim—To contribute to the debate about whether growth hormone (GH) and insulin-like
growth factor 1 (IGF-1) act independently on the growth process. Methods—To describe …

Abstract GH and IGF-I are important regulators of bone homeostasis and are central to the
achievement of normal longitudinal bone growth and bone mass. Although GH may act …

There is no one cause of bone fragility; genetic and environmental factors play a part in
development of smaller bones, fewer or thinner trabeculae, and thin cortices, all of which …

Loss of estrogens or androgens increases the rate of bone remodeling by removing
restraining effects on osteoblastogenesis and osteoclastogenesis, and also causes a focal …

Background: Angiogenesis is likely critical for the process of intramembranous
osteogenesis; however, the developmental relationship between blood vessels and bone …