An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action
B Lomonte, Y Angulo, L Calderón - Toxicon, 2003 - Elsevier
In 1984, the first venom phospholipase A2 (PLA2) with a lysine substituting for the highly
conserved aspartate 49 was discovered, in the North American crotalid snake Agkistrodon p …
conserved aspartate 49 was discovered, in the North American crotalid snake Agkistrodon p …
Lysine 49 phospholipase A2 proteins
CL Ownby, HSS de Araujo, SP White, JE Fletcher - Toxicon, 1999 - Elsevier
The structures of several K49 PLA2 proteins have been determined and these differ as a
group in several regions from the closely related D49 PLA2 enzymes. One outstanding …
group in several regions from the closely related D49 PLA2 enzymes. One outstanding …
[책][B] Handbook of venoms and toxins of reptiles
SP Mackessy - 2016 - taylorfrancis.com
The Handbook of Venoms and Toxins of Reptiles offers" one-stop shop**" to all biologists,
biochemists, toxicologists, physicians, clinicians, and epidemiologists, and informed …
biochemists, toxicologists, physicians, clinicians, and epidemiologists, and informed …
Comparative study of the cytolytic activity of myotoxic phospholipases A2 on mouse endothelial (tEnd) and skeletal muscle (C2C12) cells in vitro
A rapid in vitro cytolytic effect of some myotoxic phospholipases A2 (PLA2s) isolated from
the venoms of Viperidae snakes has been previously described. This study was undertaken …
the venoms of Viperidae snakes has been previously described. This study was undertaken …
Snake venomics and antivenomics of the arboreal neotropical pitvipers Bothriechis lateralis and Bothriechis schlegelii
B Lomonte, J Escolano, J Fernández… - Journal of proteome …, 2008 - ACS Publications
We report the comparative proteomic characterization of the venoms of two related
neotropical arboreal pitvipers from Costa Rica of the genus Bothriechis, B. lateralis (side …
neotropical arboreal pitvipers from Costa Rica of the genus Bothriechis, B. lateralis (side …
Snake venoms are integrated systems, but abundant venom proteins evolve more rapidly
SD Aird, S Aggarwal, A Villar-Briones, MMY Tin… - BMC genomics, 2015 - Springer
Background While many studies have shown that extracellular proteins evolve rapidly, how
selection acts on them remains poorly understood. We used snake venoms to understand …
selection acts on them remains poorly understood. We used snake venoms to understand …
The phospholipase A2 homologues of snake venoms: biological activities and their possible adaptive roles
A particular subgroup of toxins with phospholipase A2 (PLA2) structure, but devoid of this
enzymatic activity, is commonly found in the venoms of snakes of the family Viperidae, and …
enzymatic activity, is commonly found in the venoms of snakes of the family Viperidae, and …
Phospholipase A2 myotoxins from Bothrops snake venoms: structure-function relationship
AM Soares, MRM Fontes, JR Giglio - Current Organic Chemistry, 2004 - benthamdirect.com
Phospholipases A2 constitute the major components from Bothrops snake venoms and have
been extensively investigated not only because they are relatively very abundant in these …
been extensively investigated not only because they are relatively very abundant in these …
Snake venom phospholipase A2 enzymes
174 Handbook of Venoms and Toxins of Reptiles enzymes, as well as with other proteins, by
covalent or noncovalent interactions. Snake venoms often contain many isoenzymes, and …
covalent or noncovalent interactions. Snake venoms often contain many isoenzymes, and …
Purification and characterization of an anticoagulant phospholipase A2 from Indian monocled cobra (Naja kaouthia) venom
R Doley, AK Mukherjee - Toxicon, 2003 - Elsevier
An anticoagulant, non-toxic phospholipase A2 was isolated from the venom of Indian
monocled cobra (Naja kaouthia) by a combination of ion-exchange chromatography on CM …
monocled cobra (Naja kaouthia) by a combination of ion-exchange chromatography on CM …