The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

Human development requires intricate cell specification and communication pathways that
allow an embryo to generate and appropriately connect more than 200 different cell types …

Ubiquitin and ubiquitin-like proteins typically use distinct machineries to facilitate diverse
functions. The immunosuppressive ubiquitin-like protein Fubi is synthesized as an N …

The protein ubiquitin is a covalent modifier of proteins, including itself. The ubiquitin system
encompasses the enzymes required for catalysing attachment of ubiquitin to substrates as …

Parkinson's disease is a common neurodegenerative disease with complex clinical features.
Autosomal recessive juvenile parkinsonism (AR-JP), maps to the long arm of chromosome 6 …

Regulation of mRNA translation offers the opportunity to diversify the expression and
abundance of proteins made from individual gene products in cells, tissues and organisms …

Complex processes are involved in the protection of cells and organisms by heat shock
proteins (hsps). Aberrant protein production due to high temperatures is prevented by the …

Ribosomes are universally conserved enzymes that carry out protein biosynthesis. Bacterial
and eukaryotic ribosomes, which share an evolutionarily conserved core, are thought to …

Cyclin degradation is the key step governing exit from mitosis and progress into the next cell
cycle. When a region in the N terminus of cyclin is fused to a foreign protein, it produces a …

Skeletal muscle atrophy is a debilitating response to starvation and many systemic diseases
including diabetes, cancer, and renal failure. We had proposed that a common set of …