Alongside the liver, white adipose tissue (WAT) is critical in regulating systemic energy
homeostasis. Although each organ has its specialised functions, they must work …

The mTOR pathway integrates a diverse set of environmental cues, such as growth factor
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …

The lysosomal degradation pathway of autophagy plays a fundamental role in cellular,
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …

The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and
metabolism with environmental inputs, including nutrients and growth factors. Extensive …

The mechanistic target of rapamycin (mTOR), master regulator of cellular metabolism, exists
in two distinct complexes: mTOR complex 1 and mTOR complex 2 (mTORC1 and 2) …

Since the discovery that rapamycin, a small molecule inhibitor of the protein kinase mTOR
(mechanistic target of rapamycin), can extend the lifespan of model organisms including …

The mechanistic target of rapamycin complex 1 (mTORC1) kinase regulates cell growth by
setting the balance between anabolic and catabolic processes. To be active, mTORC1 …

Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

The protein kinase mechanistic target of rapamycin (mTOR) functions as a central regulator
of metabolism, integrating diverse nutritional and hormonal cues to control anabolic …

Obesity is a major risk factor for cardiometabolic diseases. Nevertheless, a substantial
proportion of individuals with obesity do not suffer cardiometabolic comorbidities. The …