The site-specific delivery of antitumor agents is of importance for providing effective cancer
suppression. Poor bioavailability of anticancer compounds and the presence of biological …

Abstract The Enhanced Permeability and Retention (EPR) effect has been recognized as the
central paradigm in tumor-targeted delivery in the last decades. In the wake of this concept …

Modern drug delivery technology began in 1952 with the advent of the Spansule® sustained-
release capsule technology, which can deliver a drug for 12 h after oral administration …

Rapid development of stimuli-responsive drug delivery systems (DDSs) for tumor therapy
has raised increasing interest in recent decades, and many nanomedicines are prepared to …

Pancreatic cancer is one of the harshest and most challenging cancers to treat, often labeled
as incurable. Chemotherapy continues to be the most popular treatment yet yields a very …

The multidisciplinary approaches in treatment of cancer appear to be essential in term of
bringing benefits of several disciplines and their coordination in tumor elimination. Because …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death
worldwide. The destructive nature of the disease makes it difficult for clinicians to manage …

Pancreatic cancer (PCa) is one of the leading causes of morbidity worldwide, and
theranostic approaches are ventured. The vast stroma surrounding PCa cells has been …

Pancreatic cancer (PC) is an incurable disease with a high death rate in the world
nowadays. Gemcitabine (GEM) and Paclitaxel (PTX) are considered as references of …

Mitochondrial targeting drug delivery systems have made unprecedented progress in tumor
treatment. Nevertheless, the stability of systemic circulation and the effectiveness of tumor …