The pyridazine ring is endowed with unique physicochemical properties, characterized by
weak basicity, a high dipole moment that subtends π-π stacking interactions and robust …

Picornaviruses cover a large family of pathogens that have a major impact on human but
also on veterinary health. Although most infections in man subside mildly or …

Enterovirus D68 (EV-D68) is a member of Picornaviridae and is a causative agent of recent
outbreaks of respiratory illness in children in the United States. We report here the crystal …

Enteroviruses form an important genus within the large family of Picornaviridae. They are
small, non-enveloped (+) RNA viruses, many of which are important pathogens in human …

Chemodivergent reactions of oximes and diazo esters involving Rh-catalyzed [3+ 2]
annulation and photodriven O–H insertion have been developed to generate oxazoles and …

Herein, we describe the development of a copper-catalyzed C (sp3) amination of
unactivated secondary alkyl iodides mediated by diaryliodonium salts. Our protocol is …

The hydrophobic pocket within viral capsid protein 1 is a target to combat the rhino-and
enteroviruses (RV and EV) using small molecules. The highly conserved amino acids lining …

Enterovirus 71 (EV71) is a small, positive-sense, single-stranded RNA virus in the genus
Enterovirus, family Picornavirus. It causes hand, foot and mouth disease in infants and …

Non-polio enteroviruses (NPEVs), namely coxsackieviruses (CV), echoviruses (E),
enteroviruses (EV), and rhinoviruses (RV), are responsible for a wide variety of illnesses …

Piperidines are prevalent throughout Food and Drug Administration-approved drugs and
current drug candidates, and thus robust methods for preparing these heterocycles are …