Aging is a dynamic, time-dependent process that is characterized by a gradual accumulation
of cell damage. Continual functional decline in the intrinsic ability of living organisms to …

A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …

Abstract Machine learning algorithms can be trained to estimate age from brain structural
MRI. The difference between an individual's predicted and chronological age, predicted age …

Background: There is some evidence to suggest that social isolation may be associated with
poor cognitive function in later life. However, findings are inconsistent and there is wide …

The brain-age paradigm is proving increasingly useful for exploring aging-related disease
and can predict important future health outcomes. Most brain-age research uses structural …

Background Late-life depression (LLD) is considered as a prodrome to dementia and plays
a major role in the development of long-term cognitive disabilities. We aimed to estimate the …

As our brains age, we tend to experience cognitive decline and are at greater risk of
neurodegenerative disease and dementia. Symptoms of chronic neuropsychiatric diseases …

Tau pathology is a hallmark of Alzheimer's disease (AD) but also occurs in normal cognitive
aging. Using the tau PET agent 18 F-AV-1451, we examined retention patterns in cognitively …

Background Maintaining cognitive function is an important aspect of healthy ageing. In this
study, we examined age trajectories of cognitive decline in a large nationally representative …

Computerized Cognitive Training in Cognitively Healthy Older Adults: A Systematic Review and
Meta-Analysis of Effect Modifiers | PLOS Medicine Skip to main content Advertisement PLOS …