The ability to fabricate complex structures via precise and heterogeneous deposition of
biomaterials makes additive manufacturing (AM) a leading technology in the creation of …

The aim of this study was to determine the effect of the induced stress and restraint provided
by the underlying bone on the frequency-dependent storage and loss stiffness (for bone …

Cartilage provides low-friction properties and plays an essential role in diarthrodial joints. A
hydrated ground substance composed mainly of proteoglycans (PGs) and a fibrillar collagen …

Osteoarthritis (OA) is a degenerative disease that affects 25% of the world's population over
fifty years of age. It is a chronic disease of the synovial joints, primarily the hip and knee. The …

Post-traumatic osteoarthritis (PTOA) is associated with cartilage degradation, ultimately
leading to disability and decrease of quality of life. Two key mechanisms have been …

Cartilage breaks down during mechanically-mediated osteoarthritis (OA). While previous
research has begun to elucidate mechanical, structural and cellular damage in response to …

The purpose of this proof‐of‐concept study was to develop three‐dimensional patient‐
specific mechanobiological knee joint models to simulate alterations in the fixed charged …

Articular cartilage heals poorly but experiences mechanically induced damage across a
broad range of loading rates and matrix integrity. Because loading rates and matrix integrity …

Background Despite it being known that subchondral bone affects the viscoelasticity of
cartilage, there has been little research into the mechanical properties of osteochondral …

Articular cartilage is an enduring tissue. For most individuals, articular cartilage facilitates a
lifetime of pain-free ambulation, supporting millions of loading cycles from activities of daily …