NAMI-A and KP1019/1339, two iconic ruthenium anticancer drug candidates face-to-face: A case story in medicinal inorganic chemistry
NAMI-A ((ImH)[trans-RuCl4 (dmso-S)(Im)], Im= imidazole) and KP1019/1339
(KP1019=(IndH)[trans-RuCl4 (Ind) 2], Ind= indazole; KP1339= Na [trans-RuCl4 (Ind) 2]) are …
(KP1019=(IndH)[trans-RuCl4 (Ind) 2], Ind= indazole; KP1339= Na [trans-RuCl4 (Ind) 2]) are …
Thirty years of the drug candidate NAMI‐A and the myths in the field of ruthenium anticancer compounds: a personal perspective
E Alessio - European Journal of Inorganic Chemistry, 2017 - Wiley Online Library
As anticipated in the title, this contribution is basically divided into two, strictly connected,
parts. The first is a personal overview of the ruthenium drug candidate NAMI‐A, almost 30 …
parts. The first is a personal overview of the ruthenium drug candidate NAMI‐A, almost 30 …
Interactions between proteins and Ru compounds of medicinal interest: A structural perspective
A Merlino - Coordination Chemistry Reviews, 2016 - Elsevier
Ruthenium compounds have unique physicochemical properties that can be efficiently
exploited in medicinal chemistry. These molecules can act using both DNA or enzymes as …
exploited in medicinal chemistry. These molecules can act using both DNA or enzymes as …
Anticancer ruthenium (III) complexes and Ru (III)-containing nanoformulations: An update on the mechanism of action and biological activity
The great advances in the studies on metal complexes for the treatment of different cancer
forms, starting from the pioneering works on platinum derivatives, have fostered an …
forms, starting from the pioneering works on platinum derivatives, have fostered an …
Advantageous reactivity of unstable metal complexes: Potential applications of metal-based anticancer drugs for intratumoral injections
Injections of highly cytotoxic or immunomodulating drugs directly into the inoperable tumor is
a procedure that is increasingly applied in the clinic and uses established Pt-based drugs. It …
a procedure that is increasingly applied in the clinic and uses established Pt-based drugs. It …
Protein metalation by metal-based drugs: X-ray crystallography and mass spectrometry studies
The combined use of X-ray crystallography and mass spectrometry represents a valuable
strategy to investigate and characterize protein metalation induced by anticancer metal …
strategy to investigate and characterize protein metalation induced by anticancer metal …
Ruthenium (II) carbon monoxide releasing molecules: Structural perspective, antimicrobial and anti-inflammatory properties
Carbon monoxide has recently emerged to promote tissue regeneration, enhance the innate
immune system, and have anti-inflammatory and antibacterial properties. While the first …
immune system, and have anti-inflammatory and antibacterial properties. While the first …
Gold metalation of proteins: Structural studies
Gold compounds have emerged as a novel class of metallodrugs with a promising future in
medicinal inorganic chemistry. Despite gold compounds have been intensively investigated …
medicinal inorganic chemistry. Despite gold compounds have been intensively investigated …
Ferritin-based anticancer metallodrug delivery: Crystallographic, analytical and cytotoxicity studies
The encapsulation of anticancer metal-based drugs within a protein nanocage represents a
valuable strategy to improve the efficacy and selectivity of these compounds towards cancer …
valuable strategy to improve the efficacy and selectivity of these compounds towards cancer …
Anthracenyl Functionalization of Half-Sandwich Carbene Complexes: In Vitro Anticancer Activity and Reactions with Biomolecules
N-Heterocyclic carbene (NHC) ligands are widely investigated in medicinal inorganic
chemistry. Here, we report the preparation and characterization of a series of half-sandwich …
chemistry. Here, we report the preparation and characterization of a series of half-sandwich …