[HTML][HTML] A critical role for X-chromosome architecture in mammalian X-chromosome dosage compensation
Highlights•XIST first mediates dampening, then silencing of X-linked genes in human
development•Complete gene silencing on the inactive X requires chromatin …
development•Complete gene silencing on the inactive X requires chromatin …
Compensation of gene dosage on the mammalian X
Changes in gene dosage can have tremendous evolutionary potential (eg whole-genome
duplications), but without compensatory mechanisms, they can also lead to gene …
duplications), but without compensatory mechanisms, they can also lead to gene …
[HTML][HTML] Unleashing XIST from X-chromosome inactivation
C Morey, C Rougeulle, JF Ouimette - Current Opinion in Cell Biology, 2025 - Elsevier
Recognition that the most abundant class of genes present in the human genome are those
producing long noncoding RNA (lncRNA) has hyped research on this category of transcripts …
producing long noncoding RNA (lncRNA) has hyped research on this category of transcripts …
[HTML][HTML] Building a Human Ovarian Antioxidant ceRNA Network “OvAnOx”: A Bioinformatic Perspective for Research on Redox-Related Ovarian Functions and …
C Tatone, G Di Emidio, R Battaglia, C Di Pietro - Antioxidants, 2024 - mdpi.com
The ovary is a major determinant of female reproductive health. Ovarian functions are mainly
related to the primordial follicle pool, which is gradually lost with aging. Ovarian aging and …
related to the primordial follicle pool, which is gradually lost with aging. Ovarian aging and …
Identifying potential genes driving ferroptosis in the substantia nigra and dopaminergic neurons in Parkinson's disease
A Chakrabarti, S Verma - Molecular and Cellular Neuroscience, 2025 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder marked by dopaminergic (DA)
neuron degeneration in the substantia nigra (SN). Conventional dopamine replacement …
neuron degeneration in the substantia nigra (SN). Conventional dopamine replacement …
X-chromosome inactivation: a historic topic that's still hot
YM Rodriguez, M Borensztein - 2023 - journals.biologists.com
The last edition of the X-chromosome inactivation (XCI) meeting was held as an EMBO
workshop in Berlin on 19-22 June 2023. The conference took place at the Harnack-haus in …
workshop in Berlin on 19-22 June 2023. The conference took place at the Harnack-haus in …
[HTML][HTML] Régulation du chromosome X et spécificités fonctionnelles des cellules femelles-Deux X valent-ils mieux qu'un?
J Chaumeil, C Morey - médecine/sciences, 2024 - medecinesciences.org
Et si posséder deux chromosomes X conférait aux cellules femelles des spécificités
exclusives et expliquait les différences de susceptibilité des hommes et des femmes à …
exclusives et expliquait les différences de susceptibilité des hommes et des femmes à …
A Novel XACT lncRNA Transcript with Functions Transcending X-Chromosome Inactivation.
P Zhang, PH Angles, H Zhang, T Li, R Mulet-Lazaro… - bioRxiv, 2025 - biorxiv.org
X-chromosome inactivation (XCI) is initiated during early mammalian embryogenesis by a
long non-coding RNA (lncRNA) XIST, which coats one of the two X-chromosomes and …
long non-coding RNA (lncRNA) XIST, which coats one of the two X-chromosomes and …
Regulatory mechanisms of gene expression during development
R Galupa - 2024 - hal.science
My research has been dedicated to dissecting regulatory mechanisms of gene expression,
especially at the transcriptional level. By chance, a fortunate one, I started investigating gene …
especially at the transcriptional level. By chance, a fortunate one, I started investigating gene …
Combination of human and mouse XIST domains generates a minimal functional XIST
MJ Navarro Cobos - 2024 - open.library.ubc.ca
X-chromosome inactivation (XCI) is an essential process in eutherian mammals to
compensate dosage between females and males. XCI is triggered by XIST, a long non …
compensate dosage between females and males. XCI is triggered by XIST, a long non …