Interventions for Frailty Among Older Adults With Cardiovascular Disease: JACC State-of-the-Art Review

N Ijaz, B Buta, QL Xue, DT Mohess, A Bushan… - Journal of the American …, 2022 - jacc.org
With the aging of the world's population, a large proportion of patients seen in
cardiovascular practice are older adults, but many patients also exhibit signs of physical …

Measuring biological aging in humans: A quest

L Ferrucci, M Gonzalez‐Freire, E Fabbri… - Aging cell, 2020 - Wiley Online Library
The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

MiRNA‐sequence indicates that mesenchymal stem cells and exosomes have similar mechanism to enhance cardiac repair

L Shao, Y Zhang, B Lan, J Wang… - BioMed research …, 2017 - Wiley Online Library
Mesenchymal stem cells (MSCs) repair infarcted heart through paracrine mechanism. We
sought to compare the effectiveness of MSCs and MSC‐derived exosomes (MSC‐Exo) in …

Rebuilding the damaged heart: mesenchymal stem cells, cell-based therapy, and engineered heart tissue

S Golpanian, A Wolf, KE Hatzistergos… - Physiological …, 2016 - journals.physiology.org
Mesenchymal stem cells (MSCs) are broadly distributed cells that retain postnatal capacity
for self-renewal and multilineage differentiation. MSCs evade immune detection, secrete an …

Allogeneic human mesenchymal stem cells in patients with idiopathic pulmonary fibrosis via intravenous delivery (AETHER): a phase I safety clinical trial

MK Glassberg, J Minkiewicz, RL Toonkel, ES Simonet… - Chest, 2017 - Elsevier
Background Despite Food and Drug Administration approval of 2 new drugs for idiopathic
pulmonary fibrosis (IPF), curative therapies remain elusive and mortality remains high …

[HTML][HTML] Advances of Schwann cells in peripheral nerve regeneration: from mechanism to cell therapy

C Wei, Y Guo, Z Ci, M Li, Y Zhang, Y Zhou - Biomedicine & …, 2024 - Elsevier
Peripheral nerve injuries (PNIs) frequently occur due to various factors, including
mechanical trauma such as accidents or tool-related incidents, as well as complications …

Mesenchymal stem cell senescence and rejuvenation: current status and challenges

X Zhou, Y Hong, H Zhang, X Li - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Over the past decades, mesenchymal stem cell (MSC)-based therapy has been intensively
investigated and shown promising results in the treatment of various diseases due to their …

Frailty biomarkers under the perspective of geroscience: a narrative review

RSSA Gonçalves, ÁCC Maciel, Y Rolland… - Ageing Research …, 2022 - Elsevier
Cellular and molecular aging biomarkers might contribute to identify at-risk individuals for
frailty before overt clinical manifestations appear. Although studies on the associations of …

[HTML][HTML] Aging and mesenchymal stem cells: basic concepts, challenges and strategies

M Fraile, N Eiro, LA Costa, A Martín, FJ Vizoso - Biology, 2022 - mdpi.com
Simple Summary Aging and frailty are complex processes implicating multifactorial
mechanisms, which demand for new therapeutic strategies against their devastating effects …

Application of mesenchymal stem cell therapy for aging frailty: from mechanisms to therapeutics

Y Zhu, J Ge, C Huang, H Liu, H Jiang - Theranostics, 2021 - pmc.ncbi.nlm.nih.gov
Aging frailty is a complex geriatric syndrome that becomes more prevalent with advancing
age. It constitutes a major health problem due to frequent adverse outcomes. Frailty is …