[HTML][HTML] Bile acids, intestinal barrier dysfunction, and related diseases

L Shi, L **, W Huang - Cells, 2023 - mdpi.com
The intestinal barrier is a precisely regulated semi-permeable physiological structure that
absorbs nutrients and protects the internal environment from infiltration of pathological …

An overview of drug delivery nanosystems for sepsis-related liver injury treatment

Y Lu, Y Shi, Q Wu, X Sun, WZ Zhang… - International Journal of …, 2023 - Taylor & Francis
Sepsis, which is a systemic inflammatory response syndrome caused by infection, has high
morbidity and mortality. Sepsis-related liver injury is one of the manifestations of sepsis …

Infections in burn patients

JL Kiley, DG Greenhalgh - Surgical Clinics, 2023 - surgical.theclinics.com
Infections are the leading cause of mortality in burn patients who survive initial resuscitation
1, 2 and present diagnostic and therapeutic challenges. 3 Here, the authors discuss the role …

Tackling recalcitrant Pseudomonas aeruginosa infections in critical illness via anti-virulence monotherapy

VK Singh, M Almpani, D Maura, T Kitao… - Nature …, 2022 - nature.com
Intestinal barrier derangement allows intestinal bacteria and their products to translocate to
the systemic circulation. Pseudomonas aeruginosa (PA) superimposed infection in critically …

[HTML][HTML] Glutamine promotes O-GlcNAcylation of G6PD and inhibits AGR2 S-glutathionylation to maintain the intestinal mucus barrier in burned septic mice

D Wu, S Su, X Zha, Y Wei, G Yang, Q Huang, Y Yang… - Redox Biology, 2023 - Elsevier
Mucus forms the first line of defence of the intestinal mucosa barrier, and mucin is its core
component. Glutamine is a vital energy substance for goblet cells; it can promote mucus …

Role of intestinal alkaline phosphatase in innate immunity

SB Singh, HC Lin - Biomolecules, 2021 - mdpi.com
Intestinal alkaline phosphatase (IAP) is a multi-functional protein that has been
demonstrated to primarily protect the gut. The role of IAP in maintaining intestinal …

Protective properties of intestinal alkaline phosphatase supplementation on the intestinal barrier: interactions and effects

C Gao, MY Koko, W Hong, J Gankhuyag… - Journal of Agricultural …, 2023 - ACS Publications
The intestinal barrier is critical for maintaining intestinal homeostasis, and its dysfunction is
associated with various diseases. Recent findings have revealed the multifunctional role of …

Interconnections of Pseudomonas aeruginosa quorum-sensing systems in intestinal permeability and inflammation

VK Singh, M Almpani, KM Wheeler, LG Rahme - MBio, 2023 - journals.asm.org
Quorum sensing (QS) is a highly conserved microbial communication mechanism based on
the production and sensing of secreted signaling molecules. The recalcitrant pathogen …

[HTML][HTML] Kinetics of inflammatory mediators in the immune response to burn injury: Systematic review and meta-analysis of animal studies

PPG Mulder, CR Hooijmans, M Vlig… - Journal of Investigative …, 2024 - Elsevier
Burns are often accompanied by a dysfunctional immune response, which can lead to
systemic inflammation, shock, and excessive scarring. The objective of this study was to …

Targeting the intestinal barrier to prevent gut-derived inflammation and disease: A role for intestinal alkaline phosphatase

F Kühn, R Duan, M Ilmer, U Wirth, F Adiliaghdam… - Visceral …, 2021 - karger.com
Background: Intestinal alkaline phosphatase (IAP) as a tissue-specific isozyme of alkaline
phosphatases is predominantly produced by enterocytes in the proximal small intestine. In …