Vitamin C in stem cell biology: impact on extracellular matrix homeostasis and epigenetics

CD′ Aniello, F Cermola, EJ Patriarca… - Stem cells …, 2017 - Wiley Online Library
Transcription factors and signaling molecules are well‐known regulators of stem cell identity
and behavior; however, increasing evidence indicates that environmental cues contribute to …

Effects of antioxidant supplements on the survival and differentiation of stem cells

S Shaban, MWA El-Husseny… - Oxidative Medicine …, 2017 - Wiley Online Library
Although physiological levels of reactive oxygen species (ROS) are required to maintain the
self‐renewal capacity of stem cells, elevated ROS levels can induce chromosomal …

[HTML][HTML] Therapeutic potential of dental pulp stem cells and their derivatives: Insights from basic research toward clinical applications

SM Yuan, XT Yang, SY Zhang, WD Tian… - World Journal of Stem …, 2022 - ncbi.nlm.nih.gov
For more than 20 years, researchers have isolated and identified postnatal dental pulp stem
cells (DPSCs) from different teeth, including natal teeth, exfoliated deciduous teeth, healthy …

Increasing efficiency of human mesenchymal stromal cell culture by optimization of microcarrier concentration and design of medium feed

AKL Chen, YK Chew, HY Tan, S Reuveny, SKW Oh - Cytotherapy, 2015 - Elsevier
Background aims Large amounts of human mesenchymal stromal cells (MSCs) are needed
for clinical cellular therapy. In a previous publication, we described a microcarrier-based …

[PDF][PDF] Role of signaling pathways in mesenchymal stem cell differentiation

B Bhaskar, NK Mekala, RR Baadhe… - Curr Stem Cell Res …, 2014 - researchgate.net
Mesenchymal Stem Cells (MSCs) are self-renewing cells with ability to differentiate into
organized, functional network of cells. In recent past research in develo** clinical …

Vitamin C deficiency reduces neurogenesis and proliferation in the SVZ and lateral ventricle extensions of the young guinea pig brain

N Jara, M Cifuentes, F Martínez, I González-Chavarría… - Antioxidants, 2022 - mdpi.com
Although scurvy, the severe form of vitamin C deficiency, has been almost eradicated, the
prevalence of subclinical vitamin C deficiency is much higher than previously estimated and …

Establishment of a human 3D in vitro liver-bone model as a potential system for drug toxicity screening

G Chen, Y **n, MM Hammour, B Braun, S Ehnert… - Archives of …, 2024 - Springer
Drug toxicity is an important cause of chronic liver damage, which in the long term can lead
to impaired bone homeostasis through an imbalance in the liver-bone axis. For instance …

Vitamin C induces periodontal ligament progenitor cell differentiation via activation of ERK pathway mediated by PELP1

Y Yan, W Zeng, S Song, F Zhang, W He, W Liang, Z Niu - Protein & cell, 2013 - Springer
The differentiation of periodontal ligament (PDL) progenitor cells is important for maintaining
the homeostasis of PDL tissue and alveolar bone. Vitamin C (VC), a water-soluble nutrient …

Chondrogenic differentiation of Wharton's Jelly mesenchymal stem cells on silk spidroin-fibroin mix scaffold supplemented with L-ascorbic acid and platelet rich …

A Barlian, H Judawisastra, A Ridwan, AR Wahyuni… - Scientific Reports, 2020 - nature.com
In this research, hWJ-MSCs were grown on silk scaffolds and induced towards
chondrogenesis by supplementation with L-ascorbic acid (LAA) or platelet rich plasma …

Enhanced proliferation and differentiation of mesenchymal stem cells by astaxanthin-encapsulated polymeric micelles

J Zhang, CA Peng - PLoS One, 2019 - journals.plos.org
Astaxanthin is a highly potent antioxidant which can be extracted from Haematococcus
pluvialis when cultivated and induced at high stress conditions. Due to astaxanthin's …