Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder that
heavily burdens healthcare systems worldwide. There is a significant requirement to …

Tau aggregation in neurofibrillary tangles (NFTs) is closely associated with
neurodegeneration and cognitive decline in Alzheimer's disease (AD). However, the …

Ca2+ homeostasis is essential for multiple neuronal functions and thus, Ca2+
dyshomeostasis can lead to widespread impairment of cellular and synaptic signaling …

We have generated a controlled and manipulable resource that captures genetic risk for
Alzheimer's disease: iPSC lines from 53 individuals coupled with RNA and proteomic …

Predicting the function of noncoding variation is a major challenge in modern genetics. In
this study, we used massively parallel reporter assays to screen 5706 variants identified …

During development, inflammation or tissue injury, macrophages may successively engulf
and process multiple apoptotic corpses via efferocytosis to achieve tissue homeostasis. How …

Impairments in neural lysosomal-and autophagic-mediated degradation of cellular debris
contribute to neuritic dystrophy and synaptic loss. While these are well-characterized …

Limited studies on multi-omics have been conducted to comprehensively investigate the
molecular mechanism underlying the developmental neurotoxicity of …

Unbiased data-driven omic approaches are revealing the molecular heterogeneity of
Alzheimer disease. Here, we used machine learning approaches to integrate high …

Spatial transcriptomics characterizes gene expression profiles while retaining the
information of the spatial context, providing an unprecedented opportunity to understand …