The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

Simple Summary Lung cancer is the leading cause of cancer-related death worldwide, with
an average 5-year survival rate of approximately 15%. Among the multiple histological type …

Ferroptosis is a lipid peroxidation-dependent cell death caused by metabolic dysfunction.
Ferroptosis-associated enzymes are promising therapeutic targets for cancer treatment …

Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease with
diverse drivers of disease progression and mechanisms of therapeutic resistance. We …

Lineage plasticity, a process whereby cells change their phenotype to take on a different
molecular and/or histologic identity, is a key driver of cancer progression and therapy …

Immunosurveillance of cancer requires the presentation of peptide antigens on major
histocompatibility complex class I (MHC-I) molecules,,,–. Current approaches to profiling of …

As one of the most common forms of cancer, lung cancers present as a collection of different
histological subtypes. These subtypes are characterized by distinct sets of driver mutations …

The tumor microenvironment (TME) has a significant impact on tumor growth and
immunotherapy efficacies. However, the precise cellular interactions and spatial …

Lung squamous cell carcinoma (LSCC) pathogenesis remains incompletely understood,
and biomarkers predicting treatment response remain lacking. Here, we describe novel …

Summary KRAS G12C inhibitors (adagrasib and sotorasib) have shown clinical promise in
targeting KRAS G12C-mutated lung cancers; however, most patients eventually develop …