The application of guidelines linked to the concept of drug-likeness, such as the'rule of five',
has gained wide acceptance as an approach to reduce attrition in drug discovery and …

Proteolysis targeting chimeras (PROTACs) are heterobifunctional compounds with
molecular weights and other properties that lie outside the classic 'rule-of-five'space …

Drug development has a high attrition rate, with poor pharmacokinetic and safety properties
a significant hurdle. Computational approaches may help minimize these risks. We have …

Therapeutics machine learning is an emerging field with incredible opportunities for
innovatiaon and impact. However, advancement in this field requires formulation of …

Although there has been considerable progress in molecular property prediction in
computer-aided drug design, there is a critical need to have fast and accurate models. Many …

Over the recent decades the interest in intranasal delivery as a non-invasive route for drugs
is increased. Since the nasal mucosa offers numerous benefits as a target tissue for drug …

The concept of drug-likeness, established from the analyses of the physiochemical
properties or/and structural features of existing small organic drugs or/and drug candidates …

Physiologically based pharmacokinetic (PBPK) models are useful tools in drug development
and risk assessment of environmental chemicals. PBPK model development requires the …

Over the past decade, absorption, distribution, metabolism, and excretion (ADME) property
evaluation has become one of the most important issues in the process of drug discovery …

There are numerous small molecular compounds around us to affect our health, such as
drugs, pesticides, food additives, industrial chemicals, and environmental pollutants. Over …