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Redesigning of cell-penetrating peptides to improve their efficacy as a drug delivery system
Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of
compounds into cells. Since the discovery of the first members of this peptide family, many …
compounds into cells. Since the discovery of the first members of this peptide family, many …
Poly (lysine) dendrimers form complexes with siRNA and provide its efficient uptake by myeloid cells: model studies for therapeutic nucleic acid delivery
M Gorzkiewicz, O Kopeć, A Janaszewska… - International Journal of …, 2020 - mdpi.com
The disruption of the cellular pathways of protein biosynthesis through the mechanism of
RNA interference has been recognized as a tool of great diagnostic and therapeutic …
RNA interference has been recognized as a tool of great diagnostic and therapeutic …
[HTML][HTML] Anti-CD4 antibody and dendrimeric peptide based targeted nano-liposomal dual drug formulation for the treatment of HIV infection
SP Mutalik, SY Gaikwad, G Fernandes, A More… - Life Sciences, 2023 - Elsevier
Aims Development and characterization of LAM and DTG loaded liposomes conjugated anti-
CD4 antibody and peptide dendrimer (PD2) to improve the therapeutic efficacy and to …
CD4 antibody and peptide dendrimer (PD2) to improve the therapeutic efficacy and to …
Exploring peptide dendrimers for intestinal lymphatic targeting: formulation and evaluation of peptide dendrimer conjugated liposomes for enhancing the oral …
AB Shreya, A Pandey, S Kulkarni, KV Bhaskar… - Scientific Reports, 2024 - nature.com
Asenapine maleate (ASPM) is a second-generation atypical antipsychotic that is approved
for treating acute schizophrenia and bipolar disorder in adults by the US FDA. The major …
for treating acute schizophrenia and bipolar disorder in adults by the US FDA. The major …
[HTML][HTML] Ameliorative anticancer effect of dendrimeric peptide modified liposomes of letrozole: In vitro and in vivo performance evaluations
Letrozole (LTZ) loaded dendrimeric nano-liposomes were prepared for targeted delivery to
breast cancer cells. Surface modification with cationic peptide dendrimers (PDs) and a …
breast cancer cells. Surface modification with cationic peptide dendrimers (PDs) and a …
Surface-engineered nanoliposomes with lipidated and non-lipidated peptide-dendrimeric scaffold for efficient transdermal delivery of a therapeutic agent …
The current study aimed to develop novel peptide dendrimer (PD)-conjugated
nanoliposomal formulations of asenapine maleate (ASP) for improvement in the transdermal …
nanoliposomal formulations of asenapine maleate (ASP) for improvement in the transdermal …
[HTML][HTML] Comparison of Structure and Local Dynamics of Two Peptide Dendrimers with the Same Backbone but with Different Side Groups in Their Spacers
SE Mikhtaniuk, VV Bezrodnyi, OV Shavykin, IM Neelov… - Polymers, 2020 - mdpi.com
In this paper, we perform computer simulation of two lysine-based dendrimers with Lys-2Lys
and Lys-2Gly repeating units. These dendrimers were recently studied experimentally by …
and Lys-2Gly repeating units. These dendrimers were recently studied experimentally by …
Redox sensitive self-assembling dipeptide for sustained intracellular drug delivery
The rational design and synthesis of molecules with functional supramolecular assemblies
continues to be a challenging endeavor. Self-assembled nano-and microstructures from …
continues to be a challenging endeavor. Self-assembled nano-and microstructures from …
Cellular delivery of doxorubicin mediated by disulfide reduction of a peptide-dendrimer bioconjugate
KE Burns, JB Delehanty - International Journal of Pharmaceutics, 2018 - Elsevier
In this study, we developed a peptide-dendrimer-drug conjugate system for the pH-triggered
direct cytosolic delivery of the cancer chemotherapeutic doxorubicin (DOX) using the pH …
direct cytosolic delivery of the cancer chemotherapeutic doxorubicin (DOX) using the pH …
Development of a hybrid peptide dendrimer micellar carrier system and its application in the reformulation of a hydrophobic therapeutic agent derived from traditional …
The discovery that a cane toad poison-derived steroid, bufalin can significantly impact
cancer cell proliferation supports its potential use in cancer therapy. However, its poor …
cancer cell proliferation supports its potential use in cancer therapy. However, its poor …