Mitochondria, with their intricate networks of functions and information processing, are
pivotal in both health regulation and disease progression. Particularly, mitochondrial …

Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s),
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …

Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of
molecules with oxidizing properties known as ROS. Despite those molecules being implied …

Aging is a complex process that features a functional decline in many organelles. Although
mitochondrial dysfunction is suggested as one of the determining factors of aging, the role of …

Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …

Aging is a complex and multifaceted process involving a variety of interrelated molecular
mechanisms and cellular systems. Phenotypically, the biological aging process is …