Vitamin E (alpha-tocopherol) is an essential micronutrient and fat-soluble antioxidant with
proposed role in protecting tissues from uncontrolled lipid peroxidation. This vitamin has …

Vitamin E is a group of isoprenoid chromanols with different biological activities. It comprises
eight oil‐soluble compounds: four tocopherols, namely, α‐, β‐, γ‐, and δ‐tocopherols; and …

Lipids are oxidized in vivo by multiple oxidizing species with different properties, some by
regulated manner to produce physiological mediators, while others by random mechanisms …

Over the last two decades, liquid chromatography coupled to mass-spectrometry (LC‒MS)
has become the gold standard to perform qualitative and quantitative analyses of small …

Glutamate-mediated excitotoxicity, neuroinflammation, and oxidative stress are common
underlying events in neurodegeneration. This pathogenic “triad” characterizes the …

Natural forms of vitamin E comprise four tocopherols and four tocotrienols. During the last
twenty years, there have been breakthroughs in our understanding of vitamin E metabolism …

Systemic vitamin E metabolites have been proposed as signaling molecules, but their
physiological role is unknown. Here we show, by library screening of potential human …

Abstract α‐Tocopherol is the only tocopherol that has been shown to prevent the human
deficiency disease Ataxia with Isolated Vitamin E Deficiency (AVED), and thus it is the only …

The disruption of balance between production of reactive oxygen species and antioxidant
systems in favor of the oxidants is termed oxidative stress (OS). To counteract the damaging …

The metabolism of α-tocopherol (α-TOH, vitamin E) shows marked interindividual variability,
which may influence the response to nutritional and therapeutic interventions with this …