The mucosa of the body of the stomach (ie, the gastric corpus) uses 2 overlap**, depth-
dependent mechanisms to respond to injury. Superficial injury heals via surface cells with …

Subjected to countless daily injuries, the stomach still functions as a remarkably efficient
digestive organ and microbial filter. In this Review, we follow the lead of the earliest …

Regulatory T cells (Treg) are abundant in human and mouse pancreatic cancer. To
understand the contribution to the immunosuppressive microenvironment, we depleted …

Intestinal organoid transplantation is a promising therapy for the treatment of mucosal injury.
However, how the transplanted organoids regulate the immune microenvironment of …

Background & Aims Chronic atrophic gastritis can lead to gastric metaplasia and increase
risk of gastric adenocarcinoma. Metaplasia is a precancerous lesion associated with an …

Background & Aims Metaplasia in the stomach is highly associated with development of
intestinal-type gastric cancer. Two types of metaplasias, spasmolytic polypeptide-expressing …

The gastrointestinal mucosae provide a critical barrier between the external and internal
milieu. Thus, damage to the mucosa requires an immediate response to provide appropriate …

Ethnopharmacological relevance Spasmolytic polypeptide-expressing metaplasia (SPEM) is
characterized by mucus cell morphologies at the base of gastric glands, which is considered …

Background & Aims WAP 4-disulfide core domain protein 2 (WFDC2), also known as human
epididymis protein 4, is a small secretory protein that is highly expressed in fibrosis and …

Background & Aims It is well established that chronic inflammation promotes gastric cancer–
associated metaplasia, but little is known regarding the mechanisms by which immune cells …