Abstract Several studies in Bioinformatics, Computational Biology and Systems Biology rely
on the definition of physico-chemical or mathematical models of biological systems at …

Hardware accelerators are becoming increasingly commonplace in delivering high
performance computing solutions at a fraction of the cost of conventional supercomputers …

Aneuploidy that arises during meiosis and/or mitosis is a major contributor to early embryo
loss. We previously showed that human preimplantation embryos encapsulate …

While the sequencing capability of modern instruments continues to increase exponentially,
the computational problem of map** short sequenced reads to a reference genome still …

Computational biology sequence alignment tools using the Burrows-Wheeler Transform
(BWT) are widely used in next-generation sequencing (NGS) analysis. However, despite …

Sequence alignment is the most time-consuming step in the genome analysis pipeline.
Since sequence alignment generally follows the seed-and-extension paradigm, prior …

Embryonic aneuploidy is highly complex, often leading to developmental arrest, implantation
failure or spontaneous miscarriage in both natural and assisted reproduction. Despite our …

The digital era brings up on one hand massive amounts of available data and on the other
hand the need of parallel computing architectures for efficient data processing. String …

As sequencing technologies progress, the amount of data produced grows exponentially,
shifting the bottleneck of discovery towards the data analysis phase. In particular, currently …

Since their emergence around 2006, Next-Generation Sequencing technologies have been
revolutionizing biological and medical research. Obtaining instantly an extensive amount of …