Mid-infrared photothermal microscopy: principle, instrumentation, and applications

Q **a, J Yin, Z Guo, JX Cheng - The Journal of Physical Chemistry …, 2022‏ - ACS Publications
Midinfrared photothermal (MIP) microscopy, also called optical photothermal infrared (O-
PTIR) microscopy, is an emerging tool for bond-selective chemical imaging of living …

Bond-selective imaging by optically sensing the mid-infrared photothermal effect

Y Bai, J Yin, JX Cheng - Science advances, 2021‏ - science.org
Mid-infrared (IR) spectroscopic imaging using inherent vibrational contrast has been broadly
used as a powerful analytical tool for sample identification and characterization. However …

Depth-resolved mid-infrared photothermal imaging of living cells and organisms with submicrometer spatial resolution

D Zhang, C Li, C Zhang, MN Slipchenko, G Eakins… - Science …, 2016‏ - science.org
Chemical contrast has long been sought for label-free visualization of biomolecules and
materials in complex living systems. Although infrared spectroscopic imaging has come a …

Mid-infrared photothermal imaging: Instrument and Life science applications

X Teng, M Li, H He, D Jia, J Yin, R Bolarinho… - Analytical …, 2024‏ - ACS Publications
Understanding biological processes at the molecular level is crucial for advancements in life
science, including disease diagnosis, pharmacology, and biotechnology. Visualizing …

Mid-infrared photothermal imaging of active pharmaceutical ingredients at submicrometer spatial resolution

C Li, D Zhang, MN Slipchenko, JX Cheng - Analytical chemistry, 2017‏ - ACS Publications
Chemical imaging with sufficient spatial resolution to resolve microparticles in tablets is
essential to ensure high quality and efficacy in controlled release. The existing modalities …

Bond-selective imaging of cells by mid-infrared photothermal microscopy in high wavenumber region

Y Bai, D Zhang, C Li, C Liu… - The Journal of Physical …, 2017‏ - ACS Publications
Using a visible beam to probe the thermal effect induced by infrared absorption, mid-infrared
photothermal (MIP) microscopy allows bond-selective chemical imaging at submicron …

[HTML][HTML] A tutorial on optical photothermal infrared (O-PTIR) microscopy

CB Prater, M Kansiz, JX Cheng - APL photonics, 2024‏ - pubs.aip.org
This tutorial reviews the rapidly growing field of optical photothermal infrared (O-PTIR)
spectroscopy and chemical imaging. O-PTIR is an infrared super-resolution measurement …

[HTML][HTML] Emerging trends and opportunities in discrete-frequency infrared and Raman spectroscopic imaging

R Bhargava, TP Wrobel, MR Kole - 2016‏ - spectroscopyonline.com
Recent advances in instrumentation have enabled new forms of vibrational chemical
imaging, including discrete frequency infrared (DFIR) microscopy and stimulated Raman …

Asymmetric interferometric optical photothermal infrared spectroscopy

C Prater, D Grigg, D Decker - US Patent 11,480,518, 2022‏ - Google Patents
9,134,341 B2 9,250,061 B2 9,372,154 B2 9,658,247 B2 9,841,324 B2 10,228,388 B2
10,228,389 B2 10,241,131 B2 10,473,693 B2 10,677,722 B2 10,696,405 B2 10,845,248 B1 …

Fluorescence enhanced photothermal infrared spectroscopy and confocal fluorescence imaging

C Prater - US Patent 11,519,861, 2022‏ - Google Patents
Embodiments disclosed include methods and apparatus for Fluorescent Enhanced
Photothermal Infrared (FE-PTIR) spectroscopy and chemical imaging, which enables high …