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A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Aβ oligomers from Alzheimer's brain
It is increasingly accepted that early cognitive impairment in Alzheimer's disease results in
considerable part from synaptic dysfunction caused by the accumulation of a range of …
considerable part from synaptic dysfunction caused by the accumulation of a range of …
Dissipative particle dynamics simulations in colloid and Interface science: A review
Dissipative particle dynamics (DPD) is one of the most efficient mesoscale coarse-grained
methodologies for modeling soft matter systems. Here, we comprehensively review the …
methodologies for modeling soft matter systems. Here, we comprehensively review the …
Early onset diagnosis in Alzheimer's disease patients via amyloid-β oligomers-sensing probe in cerebrospinal fluid
Amyloid-β (Aβ) oligomers are implicated in the onset of Alzheimer's disease (AD). Herein,
quinoline-derived half-curcumin-dioxaborine (Q-OB) fluorescent probe was designed for …
quinoline-derived half-curcumin-dioxaborine (Q-OB) fluorescent probe was designed for …
Exploring amyloid oligomers with peptide model systems
The assembly of amyloidogenic peptides and proteins, such as the β-amyloid peptide, α-
synuclein, huntingtin, tau, and islet amyloid polypeptide, into amyloid fibrils and oligomers is …
synuclein, huntingtin, tau, and islet amyloid polypeptide, into amyloid fibrils and oligomers is …
Stable trap** of multiple proteins at physiological conditions using nanoscale chambers with macromolecular gates
The possibility to detect and analyze single or few biological molecules is very important for
understanding interactions and reaction mechanisms. Ideally, the molecules should be …
understanding interactions and reaction mechanisms. Ideally, the molecules should be …
Light, water, and melatonin: the synergistic regulation of phase separation in dementia
The swift rise in acceptance of molecular principles defining phase separation by a broad
array of scientific disciplines is shadowed by increasing discoveries linking phase …
array of scientific disciplines is shadowed by increasing discoveries linking phase …
Rational design of photoactivatable metal complexes to target and modulate amyloid-β peptides
The accumulation of amyloid-β (Aβ) aggregates is found in the brains of Alzheimer's disease
patients. Thus, numerous efforts have been made to develop chemical reagents capable of …
patients. Thus, numerous efforts have been made to develop chemical reagents capable of …
VANL-100 attenuates beta-amyloid-induced toxicity in SH-SY5Y cells
Antioxidants are being explored as novel therapeutics for the treatment of
neurodegenerative diseases such as Alzheimer's disease (AD) through strategies such as …
neurodegenerative diseases such as Alzheimer's disease (AD) through strategies such as …
Reducing the assemblies of amyloid-beta multimers by sodium dodecyl sulfate surfactant at concentrations lower than critical micelle concentration: molecular …
Amyloid-β peptide, the predominant proteinaceous component of senile plaques, is
responsible for the incidence of Alzheimer's disease (AD), an age-associated …
responsible for the incidence of Alzheimer's disease (AD), an age-associated …
Interactions of the aβ (1–42) peptide with boron nitride nanoparticles of varying curvature in an aqueous medium: Different pathways to inhibit β-sheet formation
The aggregation of amyloid β (Aβ) peptide triggered by its conformational changes leads to
the commonly known neurodegenerative disease of Alzheimer's. It is believed that the …
the commonly known neurodegenerative disease of Alzheimer's. It is believed that the …