Definitive haematopoiesis is the process by which haematopoietic stem cells, located in the
bone marrow, generate all haematopoietic cell lineages in healthy adults. Although highly …

Ferroptosis is triggered by a chain of intracellular labile iron‐dependent peroxidation of cell
membrane phospholipids. Ferroptosis is important not only as a cause of ischaemic and …

Sepsis is a systemic response to infection with life-threatening consequences. Our
understanding of the molecular and cellular impact of sepsis across organs remains …

Protoporphyrin IX iron complex (heme) is an important cofactor for oxygen transfer, oxygen
storage, oxygen activation, and electron transfer when bound to the heme proteins …

Myelopoiesis ensures the steady state of the myeloid cell compartment. Technological
advances in fate map** and genetic engineering, as well as the advent of single cell RNA …

Trained immunity defines long-lasting adaptations of innate immunity based on
transcriptional and epigenetic modifications of myeloid cells and their bone marrow …

Background Selectively targeting leukemia stem cells (LSCs) is a promising approach in
treating acute myeloid leukemia (AML), for which identification of such therapeutic targets is …

Macrophages are an integral part of the mononuclear phagocyte system that is critical for
maintaining immune homeostasis. They play a key role for initiation and modulation of …

Differentiation of hematopoietic stem and progenitor cells is tightly regulated depending on
environmental changes in order to maintain homeostasis. Transcription factors direct the …

BTB and CNC homology 1 (BACH1) represses the expression of genes involved in the
metabolism of iron, heme and reactive oxygen species. While BACH1 is rapidly degraded …