Antiviral and antimicrobial nucleoside derivatives: structural features and mechanisms of action
The emergence of new viruses and resistant strains of pathogenic microorganisms has
become a powerful stimulus in the search for new drugs. Nucleosides are a promising class …
become a powerful stimulus in the search for new drugs. Nucleosides are a promising class …
Targeting the RdRp of emerging RNA viruses: the structure-based drug design challenge
The RNA-dependent RNA polymerase (RdRp) is an essential enzyme for the viral
replication process, catalyzing the viral RNA synthesis using a metal ion-dependent …
replication process, catalyzing the viral RNA synthesis using a metal ion-dependent …
Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase
Hepatitis C virus (HCV) infection is a global health problem that impacts approximately 180
million individuals. Of those initially infected with HCV approximately 80% will progress to …
million individuals. Of those initially infected with HCV approximately 80% will progress to …
The design of drugs for HIV and HCV
ED Clercq - Nature reviews Drug discovery, 2007 - nature.com
Since the discovery of the human immunodeficiency virus (HIV) in 1983, dramatic progress
has been made in the development of novel antiviral drugs. The HIV epidemic fuelled the …
has been made in the development of novel antiviral drugs. The HIV epidemic fuelled the …
Challenges and successes in develo** new therapies for hepatitis C
R De Francesco, G Migliaccio - Nature, 2005 - nature.com
Hepatitis C virus (HCV) will continue to be a serious global health threat for many years to
come because of the chronic nature of the infection, its high prevalence and the significant …
come because of the chronic nature of the infection, its high prevalence and the significant …
A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties
DB Olsen, AB Eldrup, L Bartholomew… - Antimicrobial agents …, 2004 - Am Soc Microbiol
Improved treatments for chronic hepatitis C virus (HCV) infection are needed due to the
suboptimal response rates and deleterious side effects associated with current treatment …
suboptimal response rates and deleterious side effects associated with current treatment …
Inhibitors of the hepatitis C virus polymerase; mode of action and resistance
The hepatitis C virus (HCV) is a pandemic human pathogen posing a substantial health and
economic burden in both develo** and developed countries. Controlling the spread of …
economic burden in both develo** and developed countries. Controlling the spread of …
Drug design strategies to avoid resistance in direct-acting antivirals and beyond
Drug resistance is prevalent across many diseases, rendering therapies ineffective with
severe financial and health consequences. Rather than accepting resistance after the fact …
severe financial and health consequences. Rather than accepting resistance after the fact …
PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus …
AM Lam, E Murakami, C Espiritu… - Antimicrobial agents …, 2010 - Am Soc Microbiol
The hepatitis C virus (HCV) NS5B RNA polymerase facilitates the RNA synthesis step during
the HCV replication cycle. Nucleoside analogs targeting the NS5B provide an attractive …
the HCV replication cycle. Nucleoside analogs targeting the NS5B provide an attractive …
Performance evaluation of Malathion biodegradation in batch and continuous packed bed bioreactor (PBBR)
The aim of this work was to study the biodegradation of Malathion in batch and continuous
packed bed (Polyurethane foam; PUF) bioreactor (PBBR). After 10 days, 89% Malathion …
packed bed (Polyurethane foam; PUF) bioreactor (PBBR). After 10 days, 89% Malathion …