Toxicology and pharmacology of synthetic organoselenium compounds: An update

CW Nogueira, NV Barbosa, JBT Rocha - Archives of Toxicology, 2021 - Springer
Here, we addressed the pharmacology and toxicology of synthetic organoselenium
compounds and some naturally occurring organoselenium amino acids. The use of …

tRNA therapeutics for genetic diseases

J Coller, Z Ignatova - Nature Reviews Drug Discovery, 2024 - nature.com
Transfer RNAs (tRNAs) have a crucial role in protein synthesis, and in recent years, their
therapeutic potential for the treatment of genetic diseases—primarily those associated with a …

tRNAscan-SE 2.0: improved detection and functional classification of transfer RNA genes

PP Chan, BY Lin, AJ Mak, TM Lowe - Nucleic acids research, 2021 - academic.oup.com
Abstract tRNAscan-SE has been widely used for transfer RNA (tRNA) gene prediction for
over twenty years, developed just as the first genomes were decoded. With the massive …

[KİTAP][B] Amino acids: biochemistry and nutrition

G Wu - 2021 - taylorfrancis.com
Following its predecessor, the second edition of Amino Acids: Biochemistry and Nutrition
presents exhaustive coverage of amino acids in the nutrition, metabolism and health of …

Selenoproteins and tRNA-Sec: regulators of cancer redox homeostasis

SL DeAngelo, B Győrffy, M Koutmos, YM Shah - Trends in Cancer, 2023 - cell.com
In the past two decades significant progress has been made in uncovering the biological
function of selenium. Selenium, an essential trace element, is required for the biogenesis of …

A genome sequence for Biomphalaria pfeifferi, the major vector snail for the human-infecting parasite Schistosoma mansoni

L Bu, L Lu, MR Laidemitt, SM Zhang… - PLoS neglected …, 2023 - journals.plos.org
Background Biomphalaria pfeifferi is the world's most widely distributed and commonly
implicated vector snail species for the causative agent of human intestinal schistosomiasis …

Naturally occurring tRNAs with non-canonical structures

N Krahn, JT Fischer, D Söll - Frontiers in Microbiology, 2020 - frontiersin.org
Transfer RNA (tRNA) is the central molecule in genetically encoded protein synthesis. Most
tRNA species were found to be very similar in structure: the well-known cloverleaf secondary …

Advances in the study of the mechanism by which selenium and selenoproteins boost immunity to prevent food allergies

K Zhu, S Yang, T Li, X Huang, Y Dong, P Wang… - Nutrients, 2022 - mdpi.com
Selenium (Se) is an essential micronutrient that functions in the body mainly in the form of
selenoproteins. The selenoprotein contains 25 members in humans that exhibit a number of …

tRNA function and dysregulation in cancer

T Gupta, MG Malkin, S Huang - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Transfer RNA (tRNA) is a central component of protein synthesis and plays important roles
in epigenetic regulation of gene expression in tumors. tRNAs are also involved in many cell …

Deciphering the Role of Selenoprotein M

LGA Nunes, A Cain, C Comyns, PR Hoffmann, N Krahn - Antioxidants, 2023 - mdpi.com
Selenocysteine (Sec), the 21st amino acid, is structurally similar to cysteine but with a sulfur
to selenium replacement. This single change retains many of the chemical properties of …