Circulating tumor HPV DNA for surveillance of HPV-positive oropharyngeal squamous cell carcinoma: A narrative review

KAL Kuhs, JC Brenner, FC Holsinger… - JAMA oncology, 2023 - jamanetwork.com
Importance Human papillomavirus (HPV)–positive oropharyngeal squamous cell carcinoma
has an overall favorable prognosis, yet a subset of patients will experience devastating …

Detection of occult recurrence using circulating tumor tissue modified viral HPV DNA among patients treated for HPV-driven oropharyngeal carcinoma

BM Berger, GJ Hanna, MR Posner, EM Genden… - Clinical Cancer …, 2022 - AACR
Purpose: Despite generally favorable outcomes, 15% to 25% of patients with human
papillomavirus (HPV)-driven oropharyngeal squamous cell carcinoma (OPSCC) will have …

Cell‐free human papillomavirus‐DNA for monitoring treatment response of head and neck squamous cell carcinoma: systematic review and meta‐analysis

F Campo, J Zocchi, S Moretto, F Mazzola… - The …, 2022 - Wiley Online Library
Objectives/Hypothesis The aim of this study was to assess the value of cell‐free human
papillomavirus‐DNA (cfHPV‐DNA) as a diagnostic test for the post‐treatment surveillance of …

Analytical validation of NavDx, a cfDNA-based fragmentomic profiling assay for HPV-driven cancers

A Gunning, S Kumar, CK Williams, BM Berger… - Diagnostics, 2023 - mdpi.com
The NavDx® blood test analyzes tumor tissue modified viral (TTMV)-HPV DNA to provide a
reliable means of detecting and monitoring HPV-driven cancers. The test has been clinically …

EV‐ADD, a database for EV‐associated DNA in human liquid biopsy samples

T Tsering, M Li, Y Chen, A Nadeau… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) play a key role in cellular communication both in physiological
conditions and in pathologies such as cancer. Emerging evidence has shown that EVs are …

Cell-free HPV-DNA as a biomarker for oropharyngeal squamous cell carcinoma—a step towards personalized medicine?

N Wuerdemann, R Jain, A Adams, EJM Speel… - Cancers, 2020 - mdpi.com
Simple Summary Human papillomavirus (HPV)-related oropharyngeal squamous cell
carcinoma (OPSCC) is a distinct tumor entity with relatively favorable overall survival …

Comparing the Diagnostic Performance of Quantitative PCR, Digital Droplet PCR, and Next-Generation Sequencing Liquid Biopsies for Human Papillomavirus …

S Naegele, DA Ruiz-Torres, Y Zhao, D Goss… - The Journal of Molecular …, 2024 - Elsevier
Human papillomavirus (HPV)-associated cancers, including oropharyngeal squamous cell
carcinoma (HPV+ OPSCC), cervical cancer, and squamous cell carcinoma of the anus …

Tumor-derived exosomes and the role of liquid biopsy in human papillomavirus oropharyngeal squamous cell carcinoma

MM Allevato, JD Smith, MJ Brenner… - The Cancer …, 2023 - journals.lww.com
The global incidence of human papillomavirus–positive (HPV+) head and neck squamous
cell carcinoma (HNSCC) has surged in recent decades, with HPV+ HNSCC accounting for> …

Circulating small extracellular vesicle-based miRNA classifier for follicular thyroid carcinoma: a diagnostic study

G Li, H Wang, J Zhong, Y Bai, W Chen, K Jiang… - British Journal of …, 2024 - nature.com
Background The diagnosis of follicular thyroid carcinoma (FTC) prior to surgery remains a
major challenge in the clinic. Methods This multicentre diagnostic study involved 41 and 150 …

It is time to improve the diagnostic workup of oropharyngeal cancer with circulating tumor HPV DNA: Systematic review and meta‐analysis

F Paolini, F Campo, O Iocca, V Manciocco… - Head & …, 2023 - Wiley Online Library
The possibility of detecting circulating tumor HPV DNA (ctHPVDNA) in plasma in patients
with oropharyngeal cancer has been demonstrated in several reports. However, these data …