Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces
severe neural injuries, and is one of the leading causes of death and disability worldwide …

Osteoarthritis is a common cause of disability worldwide. Although commonly referred to as
a disease of the joint cartilage, osteoarthritis affects all joint tissues equally. The …

Acute lung injury (ALI) is an inflammatory disease with a high mortality rate. Although
typically seen in individuals with sepsis, ALI is also a major complication in severe acute …

IL (interleukin)-6 is a pivotal cytokine of innate immunity, which enacts a broad set of
physiological functions traditionally associated with host defense, immune cell regulation …

While many diseases of aging have been linked to the immunological system, immune
metrics capable of identifying the most at-risk individuals are lacking. From the blood …

Extensive research has shown that interleukin 6 (IL-6) is a multifunctional molecule that is
both proinflammatory and anti-inflammatory, depending on the context. Here, we combine …

Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

We report on molecular analyses of baseline tumor samples from the phase 3 JAVELIN
Renal 101 trial (n= 886; NCT02684006), which demonstrated significantly prolonged …

Clear cell renal cell carcinomas (ccRCCs) are highly immune infiltrated, but the effect of
immune heterogeneity on clinical outcome in ccRCC has not been fully characterized. Here …

Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …