Recent research has demonstrated that the non-coding genome plays a key role in genetic
programming and gene regulation during development as well as in health and …

The adult heart is a complex, multicellular organ that is subjected to a series of regulatory
stimuli and circuits and has poor reparative potential. Despite progress in our understanding …

Myocardial infarction is a leading cause of death among all cardiovascular diseases. The
analysis of molecular mechanisms by which the ischemic myocardium initiates repair and …

Rationale: Paracrine secretions seem to mediate therapeutic effects of human CD34+ stem
cells locally transplanted in patients with myocardial and critical limb ischemia and in animal …

Cardiovascular disease is an enormous socioeconomic burden worldwide and remains a
leading cause of mortality and disability despite significant efforts to improve treatments and …

MicroRNAs (miRNAs) are small noncoding RNAs that block translation or induce
degradation of mRNA and thereby control patterns of gene expression. Acute myocardial …

Exosomes are nanosized membrane particles that are secreted by cells that transmit
information from cell to cell. The information within exosomes prominently includes their …

Background Circulating micro RNA s (mi RNA s) are differentially regulated and selectively
packaged in microvesicles (MVs). We evaluated whether circulating vascular and …

Cardiac exosomes mediate cell-to-cell communication, stimulate or inhibit the activities of
target cells, and affect myocardial hypertrophy, injury and infarction, ventricular remodeling …

Endothelial cells are, by number, one of the most abundant cell types in the heart and active
players in cardiac physiology and pathology. Coronary angiogenesis plays a vital role in …