A Laing distal myopathy–associated proline substitution in the β-myosin rod perturbs myosin cross-bridging activity
M Buvoli, GCK Wilson, A Buvoli… - Journal of Clinical …, 2024 - Am Soc Clin Investig
Proline substitutions within the coiled-coil rod region of the β-myosin gene (MYH7) are the
predominant mutations causing Laing distal myopathy (MPD1), an autosomal dominant …
predominant mutations causing Laing distal myopathy (MPD1), an autosomal dominant …
Functional and structural roles of coiled coils
MD Hartmann - Fibrous Proteins: Structures and Mechanisms, 2017 - Springer
Coiled coils appear in countless structural contexts, as appendages to small proteins, as
parts of multi-domain proteins, and as building blocks of filaments. Although their structure is …
parts of multi-domain proteins, and as building blocks of filaments. Although their structure is …
Orientational ambiguity in septin coiled coils and its structural basis
Septins are an example of subtle molecular recognition whereby different paralogues must
correctly assemble into functional filaments important for essential cellular events such as …
correctly assemble into functional filaments important for essential cellular events such as …
Skip residues modulate the structural properties of the myosin rod and guide thick filament assembly
KC Taylor, M Buvoli, EN Korkmaz… - Proceedings of the …, 2015 - National Acad Sciences
The rod of sarcomeric myosins directs thick filament assembly and is characterized by the
insertion of four skip residues that introduce discontinuities in the coiled-coil heptad repeats …
insertion of four skip residues that introduce discontinuities in the coiled-coil heptad repeats …
A library of coiled-coil domains: from regular bundles to peculiar twists
Motivation Coiled coils are widespread protein domains involved in diverse processes
ranging from providing structural rigidity to the transduction of conformational changes. They …
ranging from providing structural rigidity to the transduction of conformational changes. They …
Structural basis for toughness and flexibility in the C-terminal passenger domain of an Acinetobacter trimeric autotransporter adhesin
Trimeric autotransporter adhesins (TAAs) on the cell surface of Gram-negative pathogens
mediate bacterial adhesion to host cells and extracellular matrix proteins. However, AtaA, a …
mediate bacterial adhesion to host cells and extracellular matrix proteins. However, AtaA, a …
Regulation of measles virus gene expression by P protein coiled-coil properties
LM Bloyet, A Schramm, C Lazert, B Raynal… - Science …, 2019 - science.org
The polymerase of negative-stranded RNA viruses consists of the large protein (L) and the
phosphoprotein (P), the latter serving both as a chaperon and a cofactor for L. We mapped …
phosphoprotein (P), the latter serving both as a chaperon and a cofactor for L. We mapped …
[HTML][HTML] βB2 W151R mutant is prone to degradation, aggregation and exposes the hydrophobic side chains in the fourth Greek Key motif
Studies have established that congenital cataract is the major cause of blindness in children
across the globe. The β-crystallin protein family is the richest and most soluble structural …
across the globe. The β-crystallin protein family is the richest and most soluble structural …
Two variants of recombinant human bone morphogenetic protein-2 (rhBMP-2) with additional protein domains: Synthesis in an Escherichia coli heterologous …
AS Karyagina, IS Boksha, TM Grunina… - Biochemistry …, 2017 - Springer
Two variants of recombinant human bone morphogenetic protein-2 (rhBMP-2) with
additional N-terminal protein domains were obtained by expression in E. coli. The N …
additional N-terminal protein domains were obtained by expression in E. coli. The N …
α/β coiled coils
Coiled coils are the best-understood protein fold, as their backbone structure can uniquely
be described by parametric equations. This level of understanding has allowed their …
be described by parametric equations. This level of understanding has allowed their …