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Thioredoxins, glutaredoxins, and peroxiredoxins—molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling
Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …
Reactive oxygen species, antioxidants, and the mammalian thioredoxin system
Reactive oxygen species (ROS) are known mediators of intracellular signaling cascades.
Excessive production of ROS may, however, lead to oxidative stress, loss of cell function …
Excessive production of ROS may, however, lead to oxidative stress, loss of cell function …
[HTML][HTML] Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration
The selenoenzyme glutathione peroxidase 4 (Gpx4) is an essential mammalian glutathione
peroxidase, which protects cells against detrimental lipid peroxidation and governs a novel …
peroxidase, which protects cells against detrimental lipid peroxidation and governs a novel …
Kinetics and mechanisms of thiol–disulfide exchange covering direct substitution and thiol oxidation-mediated pathways
Significance: Disulfides are important building blocks in the secondary and tertiary structures
of proteins, serving as inter-and intra-subunit cross links. Disulfides are also the major …
of proteins, serving as inter-and intra-subunit cross links. Disulfides are also the major …
Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities
The first disulfide linkage-employing drug conjugate that exploits the reversible nature of this
unique covalent bond was recently approved for human use. Increasing numbers of drug …
unique covalent bond was recently approved for human use. Increasing numbers of drug …
Selenium, selenoproteins and human health: a review
KM Brown, JR Arthur - Public health nutrition, 2001 - cambridge.org
Selenium is of fundamental importance to human health. It is an essential component of
several major metabolic pathways, including thyroid hormone metabolism, antioxidant …
several major metabolic pathways, including thyroid hormone metabolism, antioxidant …
[HTML][HTML] Metabolism and function of coenzyme Q
M Turunen, J Olsson, G Dallner - Biochimica et Biophysica Acta (BBA) …, 2004 - Elsevier
Coenzyme Q (CoQ) is present in all cells and membranes and in addition to be a member of
the mitochondrial respiratory chain it has also several other functions of great importance for …
the mitochondrial respiratory chain it has also several other functions of great importance for …
Thioredoxin reductase
D Mustacich, G Powis - Biochemical Journal, 2000 - portlandpress.com
The mammalian thioredoxin reductases (TrxRs) are a family of selenium-containing pyridine
nucleotide-disulphide oxidoreductases with mechanistic and sequence identity, including a …
nucleotide-disulphide oxidoreductases with mechanistic and sequence identity, including a …
[كتاب][B] Oxidation and antioxidants in organic chemistry and biology
ET Denisov, IB Afanas' ev - 2005 - taylorfrancis.com
Providing a comprehensive review of reactions of oxidation for different classes of organic
compounds and polymers, and biological processes mediated by free radicals, Oxidation …
compounds and polymers, and biological processes mediated by free radicals, Oxidation …
Protein hydration in solution: experimental observation by x-ray and neutron scattering
The structure of the protein–solvent interface is the subject of controversy in theoretical
studies and requires direct experimental characterization. Three proteins with known atomic …
studies and requires direct experimental characterization. Three proteins with known atomic …