Genomics of the major histocompatibility complex: haplotypes, duplication, retroviruses and disease
The genomic region encompassing the Major Histocompatibility Complex (MHC) contains
polymorphic frozen blocks which have developed by local imperfect sequential duplication …
polymorphic frozen blocks which have developed by local imperfect sequential duplication …
Viral ancestors of antiviral systems
LP Villarreal - Viruses, 2011 - pmc.ncbi.nlm.nih.gov
All life must survive their corresponding viruses. Thus antiviral systems are essential in all
living organisms. Remnants of virus derived information are also found in all life forms but …
living organisms. Remnants of virus derived information are also found in all life forms but …
SNP profile within the human major histocompatibility complex reveals an extreme and interrupted level of nucleotide diversity
The human major histocompatibility complex (MHC) is characterized by polymorphic
multicopy gene families, such as HLA and MIC (PERB11); duplications; insertions and …
multicopy gene families, such as HLA and MIC (PERB11); duplications; insertions and …
The widespread evolutionary significance of viruses
LP Villarreal - Origin and Evolution of Viruses, 2008 - Elsevier
In the last 30 years, the study of virus evolution has undergone a transformation. Originally
concerned with disease and its emergence, virus evolution had not been well integrated into …
concerned with disease and its emergence, virus evolution had not been well integrated into …
The Association Between HLA-A Alleles and an Alu Dimorphism Near HLA-G
JK Kulski, P Martinez, N Longman-Jacobsen… - Journal of molecular …, 2001 - Springer
Abstract The Alu Yb8 sequences are a subfamily of short interspersed Alu retroelements that
have been amplified within the human genome during recent evolutionary time and are …
have been amplified within the human genome during recent evolutionary time and are …
The human and murine protocadherin‐β one‐exon gene families show high evolutionary conservation, despite the difference in gene number
K Vanhalst, P Kools, E Vanden Eynde… - FEBS letters, 2001 - Wiley Online Library
Extensive cDNA analysis demonstrated that all human and mouse protocadherin‐β genes
are one‐exon genes. The protein sequences of these genes are highly conserved …
are one‐exon genes. The protein sequences of these genes are highly conserved …
Using alu J elements as molecular clocks to trace the evolutionary relationships between duplicated HLA class I genomic segments
The class I region of the major histocompatibility complex contains two subgenomic blocks
(250–350 kb each), known as the alpha and beta blocks. These blocks contain members of …
(250–350 kb each), known as the alpha and beta blocks. These blocks contain members of …
The phylogenetic history of the MHC class I gene families in pig, including a fossil gene predating mammalian radiation
C Renard, P Chardon, M Vaiman - Journal of molecular evolution, 2003 - Springer
More than 990 kb of the 1200 kb in the SLA class I region of the pig major histocompatibility
complex (MHC) have been sequenced. The present study was designed to establish the …
complex (MHC) have been sequenced. The present study was designed to establish the …
Duplication and Polymorphism in the MHC: Alu Generated Diversity and Polymorphism Within the PERB11 Gene Family
The PERB11 gene family has at least five members within the telomeric region of the MHC.
The PERB11. 1 and PERB11. 2 genes are approximately 40 kb and 160 kb centromeric of …
The PERB11. 1 and PERB11. 2 genes are approximately 40 kb and 160 kb centromeric of …
Transposable elements and the metamerismatic evolution of the HLA class I region
We have analysed continuous genomic sequence of 1.8 Mb from the HLA class I region of
the MHC with a view to understanding the evolution, organisation and sequential …
the MHC with a view to understanding the evolution, organisation and sequential …