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18F-Labeling of Arenes and Heteroarenes for Applications in Positron Emission Tomography
S Preshlock, M Tredwell, V Gouverneur - Chemical reviews, 2016 - ACS Publications
Diverse radiochemistry is an essential component of nuclear medicine; this includes
imaging techniques such as positron emission tomography (PET). As such, PET can track …
imaging techniques such as positron emission tomography (PET). As such, PET can track …
Chemistry for Positron Emission Tomography: Recent Advances in 11C‐, 18F‐, 13N‐, and 15O‐Labeling Reactions
X Deng, J Rong, L Wang, N Vasdev… - Angewandte Chemie …, 2019 - Wiley Online Library
Positron emission tomography (PET) is a molecular imaging technology that provides
quantitative information about function and metabolism in biological processes in vivo for …
quantitative information about function and metabolism in biological processes in vivo for …
Synthesis of [18F]Arenes via the Copper-Mediated [18F]Fluorination of Boronic Acids
AV Mossine, AF Brooks, KJ Makaravage, JM Miller… - Organic …, 2015 - ACS Publications
A copper-mediated radiofluorination of aryl-and vinylboronic acids with K18F is described.
This method exhibits high functional group tolerance and is effective for the radiofluorination …
This method exhibits high functional group tolerance and is effective for the radiofluorination …
Copper-Mediated Radiofluorination of Arylstannanes with [18F]KF
KJ Makaravage, AF Brooks, AV Mossine… - Organic …, 2016 - ACS Publications
A copper-mediated nucleophilic radiofluorination of aryl-and vinylstannanes with [18F] KF is
described. This method is fast, uses commercially available reagents, and is compatible with …
described. This method is fast, uses commercially available reagents, and is compatible with …
Enhanced copper-mediated 18 F-fluorination of aryl boronic esters provides eight radiotracers for PET applications
[18F] FMTEB,[18F] FPEB,[18F] flumazenil,[18F] DAA1106,[18F] MFBG,[18F] FDOPA,[18F]
FMT and [18F] FDA are prepared from the corresponding arylboronic esters and [18F] …
FMT and [18F] FDA are prepared from the corresponding arylboronic esters and [18F] …
Recent progress in the application of iodonium ylides in organic synthesis
X Mi, C Pi, W Feng, X Cui - Organic Chemistry Frontiers, 2022 - pubs.rsc.org
Iodonium ylides have attracted considerable attention due to their unique properties and
numerous applications as versatile and sustainable reagents in organic synthesis …
numerous applications as versatile and sustainable reagents in organic synthesis …
Mechanistic studies and radiofluorination of structurally diverse pharmaceuticals with spirocyclic iodonium (III) ylides
Synthesis of non-activated electron-rich and sterically hindered 18F-arenes remains a major
challenge due to limitations of existing radiofluorination methodologies. Herein, we report on …
challenge due to limitations of existing radiofluorination methodologies. Herein, we report on …
Difluorocarbene‐Derived Trifluoromethylthiolation and [18F]Trifluoromethylthiolation of Aliphatic Electrophiles
The first trifluoromethylthiolation and [18F] trifluoromethylthiolation of alkyl electrophiles with
in situ generated difluorocarbene in the presence of elemental sulfur and external …
in situ generated difluorocarbene in the presence of elemental sulfur and external …
Ring-Closing Synthesis of Dibenzothiophene Sulfonium Salts and Their Use as Leaving Groups for Aromatic 18F-Fluorination
T Gendron, K Sander, K Cybulska… - Journal of the …, 2018 - ACS Publications
Herein, we report a novel intramolecular ring-closing reaction of biaryl thioethers that give
access to highly functionalized dibenzothiophene sulfonium salts under mild conditions. The …
access to highly functionalized dibenzothiophene sulfonium salts under mild conditions. The …
11 C [double bond, length as m-dash] O bonds made easily for positron emission tomography radiopharmaceuticals
The positron-emitting radionuclide carbon-11 (11C, t1/2= 20.3 min) possesses the unique
potential for radiolabeling of any biological, naturally occurring, or synthetic organic …
potential for radiolabeling of any biological, naturally occurring, or synthetic organic …