Translation elongation and recoding in eukaryotes
In this review, we highlight the current understanding of translation elongation and recoding
in eukaryotes. In addition to providing an overview of the process, recent advances in our …
in eukaryotes. In addition to providing an overview of the process, recent advances in our …
Pseudomonas Exotoxin A: optimized by evolution for effective killing
M Michalska, P Wolf - Frontiers in microbiology, 2015 - frontiersin.org
Pseudomonas Exotoxin A (PE) is the most toxic virulence factor of the pathogenic bacterium
Pseudomonas aeruginosa. This review describes current knowledge about the intoxication …
Pseudomonas aeruginosa. This review describes current knowledge about the intoxication …
Novel bacterial ADP-ribosylating toxins: structure and function
NC Simon, K Aktories, JT Barbieri - Nature Reviews Microbiology, 2014 - nature.com
Bacterial ADP-ribosyltransferase toxins (bARTTs) transfer ADP-ribose to eukaryotic proteins
to promote bacterial pathogenesis. In this Review, we use prototype bARTTs, such as …
to promote bacterial pathogenesis. In this Review, we use prototype bARTTs, such as …
Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes
Oxygen is toxic across all three domains of life. Yet, the underlying molecular mechanisms
remain largely unknown. Here, we systematically investigate the major cellular pathways …
remain largely unknown. Here, we systematically investigate the major cellular pathways …
The roles of protein expression in synaptic plasticity and memory consolidation
T Rosenberg, S Gal-Ben-Ari, DC Dieterich… - Frontiers in molecular …, 2014 - frontiersin.org
The amount and availability of proteins are regulated by their synthesis, degradation, and
transport. These processes can specifically, locally, and temporally regulate a protein or a …
transport. These processes can specifically, locally, and temporally regulate a protein or a …
Iron–sulfur clusters as inhibitors and catalysts of viral replication
A virus hijacks host cellular machineries and metabolites in order to reproduce. In response,
the innate immune system activates different processes to fight back. Although many aspects …
the innate immune system activates different processes to fight back. Although many aspects …
Functions and regulation of translation elongation factors
B Xu, L Liu, G Song - Frontiers in molecular biosciences, 2022 - frontiersin.org
Translation elongation is a key step of protein synthesis, during which the nascent
polypeptide chain extends by one amino acid residue during one elongation cycle. More …
polypeptide chain extends by one amino acid residue during one elongation cycle. More …
Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling
B Wilding, D Scharn, D Boese, A Baum, V Santoro… - Nature Cancer, 2022 - nature.com
Oncogenic alterations in human epidermal growth factor receptor 2 (HER2) occur in
approximately 2% of patients with non-small cell lung cancer and predominantly affect the …
approximately 2% of patients with non-small cell lung cancer and predominantly affect the …
Wobble uridine modifications–a reason to live, a reason to die?!
Wobble uridines (U34) are generally modified in all species. U34 modifications can be
essential in metazoans but are not required for viability in fungi. In this review, we provide an …
essential in metazoans but are not required for viability in fungi. In this review, we provide an …
DNA methyltransferase inhibition overcomes diphthamide pathway deficiencies underlying CD123-targeted treatment resistance
K Togami, T Pastika, J Stephansky… - The Journal of …, 2019 - Am Soc Clin Investig
The interleukin-3 receptor α subunit, CD123, is expressed in many hematologic
malignancies including acute myeloid leukemia (AML) and blastic plasmacytoid dendritic …
malignancies including acute myeloid leukemia (AML) and blastic plasmacytoid dendritic …