Targeting the progression of chronic kidney disease
Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …
Fibrosis in chronic kidney disease: pathogenesis and consequences
S Panizo, L Martínez-Arias, C Alonso-Montes… - International journal of …, 2021 - mdpi.com
Fibrosis is a process characterized by an excessive accumulation of the extracellular matrix
as a response to different types of tissue injuries, which leads to organ dysfunction. The …
as a response to different types of tissue injuries, which leads to organ dysfunction. The …
Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches
J Beermann, MT Piccoli, J Viereck… - Physiological …, 2016 - journals.physiology.org
Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear …
coding transcripts with unknown function. There are several types of non-coding linear …
[HTML][HTML] Treatment of diabetic kidney disease: current and future
T Yamazaki, I Mimura, T Tanaka… - … & metabolism journal, 2021 - synapse.koreamed.org
Diabetic kidney disease (DKD) is the major cause of end-stage kidney disease. However,
only renin-angiotensin system inhibitor with multidisciplinary treatments is effective for DKD …
only renin-angiotensin system inhibitor with multidisciplinary treatments is effective for DKD …
TGF-β: the master regulator of fibrosis
Transforming growth factor-β (TGF-β) is the primary factor that drives fibrosis in most, if not
all, forms of chronic kidney disease (CKD). Inhibition of the TGF-β isoform, TGF-β1, or its …
all, forms of chronic kidney disease (CKD). Inhibition of the TGF-β isoform, TGF-β1, or its …
[HTML][HTML] Smad3 signatures in renal inflammation and fibrosis
W Wu, X Wang, X Yu, HY Lan - International journal of biological …, 2022 - ncbi.nlm.nih.gov
Renal inflammation and fibrosis are key pathological features of acute kidney injury (AKI)
and chronic kidney disease (CKD). Smad3 is a critical mediator of TGF-β signaling and …
and chronic kidney disease (CKD). Smad3 is a critical mediator of TGF-β signaling and …
TGF-beta as a master regulator of diabetic nephropathy
L Wang, HL Wang, TT Liu, HY Lan - International journal of molecular …, 2021 - mdpi.com
Diabetic nephropathy (DN) is one of the most common complications in diabetes mellitus
and the leading cause of end-stage renal disease. TGF-β is a pleiotropic cytokine and has …
and the leading cause of end-stage renal disease. TGF-β is a pleiotropic cytokine and has …
[HTML][HTML] Central role of dysregulation of TGF-β/Smad in CKD progression and potential targets of its treatment
L Chen, T Yang, DW Lu, H Zhao, YL Feng… - Biomedicine & …, 2018 - Elsevier
Chronic kidney disease (CKD) has emerged as a major cause of morbidity and mortality
worldwide. Interstitial fibrosis, glomerulosclerosis and inflammation play the central role in …
worldwide. Interstitial fibrosis, glomerulosclerosis and inflammation play the central role in …
TGF-β/Smad signaling in renal fibrosis
TGF-β (transforming growth factor-β) is well identified as a central mediator in renal fibrosis.
TGF-β initiates canonical and non-canonical pathways to exert multiple biological effects …
TGF-β initiates canonical and non-canonical pathways to exert multiple biological effects …
Mechanisms of diabetic complications
It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …
required, but also for its major complications, affecting both small and large blood vessels …