Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic advances

Z Yu, C Xu, B Song, S Zhang, C Chen, C Li… - Journal of translational …, 2023 - Springer
Cancer remains the leading cause of death around the world. In cancer treatment, over 50%
of cancer patients receive radiotherapy alone or in multimodal combinations with other …

FAPI PET/CT imaging—an updated review

KR Chandekar, A Prashanth, S Vinjamuri, R Kumar - Diagnostics, 2023 - mdpi.com
Despite revolutionizing the field of oncological imaging, Positron Emission Tomography
(PET) with [18F] Fluorodeoxyglucose (FDG) as its workhorse is limited by a lack of specificity …

Third-generation CD19. CAR-T cell-containing combination therapy in Scl70+ systemic sclerosis

W Merkt, M Freitag, M Claus, P Kolb… - Annals of the …, 2024 - ard.bmj.com
No effective treatment of systemic sclerosis-associated interstitial lung disease (SSc-ILD)
exists. Numerous evidences support the importance of adaptive immunity in SSc-ILD. A …

Comprehensive analysis of fibroblast activation protein expression in interstitial lung diseases

P Yang, Q Luo, X Wang, Q Fang, Z Fu, J Li… - American journal of …, 2023 - atsjournals.org
Rationale: Sustained activation of lung fibroblasts and the resulting oversynthesis of the
extracellular matrix are detrimental events for patients with interstitial lung diseases (ILDs) …

Kidney fibrosis: emerging diagnostic and therapeutic strategies

BM Klinkhammer, P Boor - Molecular Aspects of Medicine, 2023 - Elsevier
An increasing number of patients worldwide suffers from chronic kidney disease (CKD).
CKD is accompanied by kidney fibrosis, which affects all compartments of the kidney, ie, the …

Emerging molecular imaging targets and tools for myocardial fibrosis detection

AK Barton, E Tzolos, R Bing, T Singh… - European Heart …, 2023 - academic.oup.com
Myocardial fibrosis is the heart's common healing response to injury. While initially seeking
to optimize the strength of diseased tissue, fibrosis can become maladaptive, producing stiff …

Assessment of myocardial fibrosis in patients with systemic sclerosis using [68Ga]Ga-FAPI-04-PET-CT

C Treutlein, JHW Distler, K Tascilar… - European Journal of …, 2023 - Springer
Purpose Myocardial fibrosis (MF) is a factor of poor prognosis in systemic sclerosis (SSc).
Direct in-vivo visualization of fibroblast activation as early readout of MF has not been …

[64Cu]Cu-PEG-FUD peptide for noninvasive and sensitive detection of murine pulmonary fibrosis

HJ Lee, K Bernau, TJ Harr, ZT Rosenkrans… - Science …, 2024 - science.org
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease resulting in irreversible scarring
within the lungs. However, the lack of biomarkers that enable real-time assessment of …

Initial results with [18F]FAPI-74 PET/CT in idiopathic pulmonary fibrosis

Y Mori, V Kramer, E Novruzov, E Mamlins… - European Journal of …, 2024 - Springer
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease with a poor
prognosis. 68Ga-labeled FAP ligands exhibited highly promising results due to the crucial …

Predictive biomarkers of disease progression in idiopathic pulmonary fibrosis

W Zhu, C Liu, C Tan, J Zhang - Heliyon, 2024 - cell.com
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial disease that cannot be cured, and
treatment options for IPF are very limited. Early diagnosis, close monitoring of disease …