Mitochondrial dysfunction and neurological disorders: a narrative review and treatment overview
Mitochondria play a vital role in the nervous system, as they are responsible for generating
energy in the form of ATP and regulating cellular processes such as calcium (Ca 2+) …
energy in the form of ATP and regulating cellular processes such as calcium (Ca 2+) …
30 years of second-generation antiseizure medications: impact and future perspectives
Summary Since 1989, 18 second-generation antiseizure medications have reached the
market, resulting in a greatly increased range of treatment options for patients and …
market, resulting in a greatly increased range of treatment options for patients and …
On-demand cell-autonomous gene therapy for brain circuit disorders
Several neurodevelopmental and neuropsychiatric disorders are characterized by
intermittent episodes of pathological activity. Although genetic therapies offer the ability to …
intermittent episodes of pathological activity. Although genetic therapies offer the ability to …
Monogenic epilepsies: disease mechanisms, clinical phenotypes, and targeted therapies
A monogenic etiology can be identified in up to 40% of people with severe epilepsy. To
address earlier and more appropriate treatment strategies, clinicians are required to know …
address earlier and more appropriate treatment strategies, clinicians are required to know …
Current and future prospects for gene therapy for rare genetic diseases affecting the brain and spinal cord
In recent years, gene therapy has been raising hopes toward viable treatment strategies for
rare genetic diseases for which there has been almost exclusively supportive treatment. We …
rare genetic diseases for which there has been almost exclusively supportive treatment. We …
A pH-sensitive closed-loop nanomachine to control hyperexcitability at the single neuron level
Epilepsy affects 1% of the general population and 30% of patients are resistant to
antiepileptic drugs. Although optogenetics is an efficient antiepileptic strategy, the difficulty of …
antiepileptic drugs. Although optogenetics is an efficient antiepileptic strategy, the difficulty of …
Kv1. 1 channelopathies: pathophysiological mechanisms and therapeutic approaches
Kv1. 1 belongs to the Shaker subfamily of voltage-gated potassium channels and acts as a
critical regulator of neuronal excitability in the central and peripheral nervous systems …
critical regulator of neuronal excitability in the central and peripheral nervous systems …
In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy
Epilepsy is a major health burden, calling for new mechanistic insights and therapies.
CRISPR-mediated gene editing shows promise to cure genetic pathologies, although …
CRISPR-mediated gene editing shows promise to cure genetic pathologies, although …
Mechanisms for cognitive impairment in epilepsy: moving beyond seizures
There has been a major emphasis on defining the role of seizures in the causation of
cognitive impairments like memory deficits in epilepsy. Here we focus on an alternative …
cognitive impairments like memory deficits in epilepsy. Here we focus on an alternative …
Severe deficiency of the voltage-gated sodium channel NaV1. 2 elevates neuronal excitability in adult mice
Scn2a encodes the voltage-gated sodium channel Na V 1.2, a main mediator of neuronal
action potential firing. The current paradigm suggests that Na V 1.2 gain-of-function variants …
action potential firing. The current paradigm suggests that Na V 1.2 gain-of-function variants …